Fig. 3.

Effect of O. indicum Vent. extract on the histology of heart tissue (in light microscopic view – ×400) in doxorubicin induced rats. a) Cardiac histology of normal group with typical micro-architecture; (b) Doxorubicin induced untreated control group showed focal loss of tissue and fragmentation (small arrow to right), and lack of well defined boundaries of cardiac fibers indicating necrosis (big arrow pointed upwards) of cardiac tissue (b.1), cytoplasmic vacuolation (small arrow to right) and lymphocyte infiltration (big arrow pointed upwards) (b.2); c) Rats treated with Probucol (standard drug – 20 mg/kg bw) showed normal histology; Treatment with d) O. indicum extract low dose (200 mg/kg bw) revealed minimal damage and e) O. indicum extract high dose (400 mg/kg bw) showed normal cardiac tissue architecture (with hematoxylin–eosin staining).