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. 2019 Aug 5;28:107–119. doi: 10.1016/j.molmet.2019.08.003

Figure 1.

Figure 1

Novel object recognition test analysis revealed no evidence of deficits in short-term recognition memory (3 min ITI) in STZ-diabetic rats (Study 1). A) All experimental groups showed no evidence of object preference (L: left and R: right) during the 3 min acquisition (Ac) phase. B) Control (n = 10; **p < 0.01), diabetic-untreated rats (n = 9; *p < 0.05) and insulin-treated diabetic rats (n = 7; **p < 0.01) explored the novel object (N) for a significantly longer time than the familiar object (F) in the retention (R) phase. C) The Discrimination Index reveals all experimental groups preferentially explored the novel object significantly more than the familiar object. All experimental groups showed similar levels of D) locomotor activity and E) total exploration time in the Ac and R phases. All data are represented as median ± interquartile range. Data are analyzed using Wilcoxon matched-pairs test between L and R (A) or F and N (B) for each experimental group, Kruskal–Wallis test followed by Dunn's post-hoc test (C) or Freidman test followed by Dunn's post hoc test (D&E).