Table 5.

The top 24 most significant pathways of the metabolite–transcript interaction network for LUAD tumours

Pathway name	#Entities found	#Entities total	Entities ratio	Entities P‐value	Entities FDR
Haemostasis	26	812	0.058	1.95E‐09	2.85E‐06
Platelet activation, signalling and aggregation	15	293	0.021	2.19E‐08	1.60E‐05
Platelet degranulation	9	137	0.010	2.30E‐06	0.0011
Response to elevated platelet cytosolic Ca2+	9	144	0.010	3.43E‐06	0.0011
MAPK1/MAPK3 signalling	12	280	0.020	3.80E‐06	0.0011
Vasopressin regulates renal water homoeostasis via aquaporins	6	52	0.004	5.26E‐06	0.0013
RAF/MAP kinase cascade	11	273	0.020	1.73E‐05	0.0023
G alpha (q) signalling events	11	274	0.020	1.79E‐05	0.0023
MAPK family signalling cascades	12	331	0.024	2.00E‐05	0.0023
Integrin alphaIIb beta3 signalling	5	39	0.003	2.01E‐05	0.0023
Integrin signalling	5	39	0.003	2.01E‐05	0.0023
DCC‐mediated attractive signalling	4	19	0.001	2.09E‐05	0.0023
Nucleobase catabolism	8	139	0.010	2.19E‐05	0.0023
Aquaporin‐mediated transport	6	68	0.005	2.37E‐05	0.0023
FGFR1c and Klotho ligand binding and activation	3	7	0.001	2.97E‐05	0.0027
Purine catabolism	6	74	0.005	3.78E‐05	0.0032
Phosphorylation of Emi1	3	8	0.001	4.41E‐05	0.0036
Signalling by moderate kinase activity BRAF mutants	5	48	0.003	5.35E‐05	0.0038
Cell surface interactions at the vascular wall	10	256	0.018	5.49E‐05	0.0038
G alpha (i) signalling events	15	557	0.040	5.56E‐05	0.0038
Paradoxical activation of RAF signalling by kinase inactive BRAF	5	49	0.004	5.89E‐05	0.0039
Neurofascin interactions	3	9	0.001	6.24E‐05	0.0039
GPCR downstream signalling	25	1344	0.096	8.26E‐05	0.0048
Platelet aggregation (plug formation)	5	53	0.004	8.49E‐05	0.0048