Prandial glucose control is increased in VSG mice but decreased in calorically restricted controls during weight-regain following surgery. Glucose curves and integrated AUC during a mixed-meal gavage are shown for (A,B) PF-Sham animals or (C,D) VSG operated animals. Circulating levels of (E) insulin, (F) total GLP-1, (G) GIP, and (H) glucagon 10m post mixed-meal gavage. Preoperative values are shown with a black solid line, black bar or black circles, 12d MMTT values are shown with a blue dotted line, blue bar, or blue circles, 80d MMTT values are shown with a red dashed line, red bar, or red circles. Data represent mean ± SEM; * represents p-value < 0.05 compared to preoperative value; # represents p-value < 0.05 between 12d and 80d MMTT; p-values > 0.05 but <0.1 are indicated.