Figure 3.

M-AktDKO mice have reduced whole-body glucose turnover and normal insulin-stimulated uptake in skeletal muscle. Hyperinsulinemic-euglycemic clamps were performed in control and M-AktDKO mice following 5 h fasting using a 2.5 mU/kg/min infusion of insulin. (A) Steady state glucose infusion rate, (B) rate of glucose disposal, (C) glucose infusion rate normalized to lean mass, (D) glucose disposal rate normalized to lean mass, (E) hepatic glucose production during basal and insulin portion of the clamp, (F) hepatic glucose production normalized to lean mass, and (G) in vivo glucose uptake in skeletal muscle during hyperinsulinemic-euglycemic clamp (n = 4–9). (**p < 0.01, ***p < 0.001 vs. controls, ****p < 0.0001 vs. control).