Figure 5.
Anti-CD30/CEA CAR T Cells Show Superior Cancer Cell Killing In Vivo
(A and B) T cells with and without CAR (A, 5 × 106 cells/mouse, 20% CAR+; B, 2.5 × 105 cells/mouse, 30% CAR +) were co-injected with LS174T (A, 2.5 × 106/mouse) or C15A3 tumor cells (B, 106 cells/mouse) into Rag−/− cg−/− mice. Tumor volume was determined every 2–3 days until day 32. Areas under the curve (AUCs) were calculated and the mean values of 6 mice were determined. Significant differences were determined by Student's t test.