Anti-CD30/CEA CAR T Cells Express Higher Amounts of Cytotoxic Effector Molecules
(A and B) T cells with the anti-CD30/CEA (n = 9), anti-CD25/CEA (n = 5), and anti-CEA CAR (n = 9), respectively, were stained for perforin (A) and granzyme B (grzB) (B) expressions or for control with an isotype-matched antibody of irrelevant specificity (iso). Cells were analyzed by flow cytometry and mfis were determined. Data represent the mean values ± SD. Significant differences were determined using the Student’s t test.