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. 2019 Oct 30;11:67. doi: 10.1186/s13073-019-0679-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — a MSI status showed strong correlation with neoantigen burden and overall neoantigen immunogenicity score while cytolytic activity did not in stomach adenocarcinoma. b Kaplan-Meier estimates of overall survival according to mutation burden, tumor neoantigen burden (TNB), overall tumor neoantigen immunogenicity score (TNS), cytolytic activity, MSI status, and MHC II expression. The median of each value was selected as a cutoff for high vs low separation in all biomarkers except MSI status classified as MSI and MSS groups. c Univariate and multivariate Cox regression survival analyses of TCGA STAD data on different single biomarkers and all. TNB, tumor neoantigen burden; TNS, overall tumor neoantigen immunogenicity score; MSI, microsatellite instability; MSS, microsatellite stability; HR, hazard ratio; CI, confidence interval