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. 2019 Oct 18;39(10):BSR20181740. doi: 10.1042/BSR20181740

Figure 6. GAS5 regulated the proliferation of HG-induced mesangial cells and accumulation of extracellular matrix through NF-κB pathway.

Figure 6

SV40 MES-13 cells were transfected with pcDNA, or pcDNA-GAS5, or pcDNA-GAS5+si-control, or pcDNA-GAS5+si-IKK. Then, SV40 MES-13 cells were divided into NG group, HG group, HG+pcDNA group, HG+pcDNA-GAS5 group, HG+pcDNA-GAS5+si-control group, HG+pcDNA-GAS5+si-IKK group. (A) The proliferation of SV40 MES-13 cells was detected in NG group, HG group, HG+pcDNA group, HG+pcDNA-GAS5 group, HG+pcDNA-GAS5+si-control group, HG+pcDNA-GAS5+si-IKK group. (B) The levels of LN, FN and Col IV were detected in NG group, HG group, HG+pcDNA group, HG+pcDNA-GAS5 group, HG+pcDNA-GAS5+si-control group, HG+pcDNA-GAS5+si-IKK group.** P<0.01, compared with NG. ##P<0.01, compared with HG+pcDNA. &P<0.01, compared with HG+ pcDNA-GAS5+si-control.