Table 3. Significant associations between non-synonymous variants and T2D-related metabolites in KARE cohort (P<2.05 × 10⁻⁷)^*.

Metabolites§	SNP	Gene	Chr	Location	Alleles†	Amino acid change	MAF	β	P-value	Predicted functional effects
										SIFT	Polyphen
Glycine	rs1047883	CPS1	2	211456637	G/A	Ala350Thr	0.470	−0.155	2.13E-08	Tolerated	Benign
PC ae C36:0	rs2108622	CYP4F2	19	15990431	G/A	Val433Met	0.325	0.213	8.19E-13	Deleterious	Probably damaging

^*Threshold for significance has been adjusted for Bonferroni correction (P<0.05/[number of SNPs × number of T2D-related metabolites]).

^†The allele of each non-synonymous variant is indicated as ‘major allele/minor allele’.

^§PC ae C36:0, phosphatidylcholine acyl-alkyl C36:0.