Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Automatica (Oxf). 2018 Dec 10;100:336–348. doi: 10.1016/j.automatica.2018.11.012

Figure 2:

Figure 2:

Schematic of the core circadian gene regulatory network and effect of small molecule KL001. (A) The core circadian negative feedback loop. KL001 stabilizes nuclear CRY by reducing its degradation rate, as shown in blue. (B) Infinitesimal parametric phase response curve (ipPRC) for KL001-mediated stabilization of nuclear CRYs.