Table 4.
Univariate and multivariable overall survival
| Characteristic | Univariate | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age at diagnosis (years) | ||||||
| < 70 | reference | reference | ||||
| ≥ 70 | 3.37 | (1.78, 6.40) | <0.001 | 3.57 | (1.64, 7.74) | 0.001 |
| Histology | ||||||
| Mixed | reference | reference | ||||
| Pure clear cell carcinoma | 2.41 | (1.28, 4.55) | 0.007 | 1.58 | (0.75, 3.36) | 0.232 |
| FIGO stage | ||||||
| IA | reference | reference | ||||
| IB | 0.82 | (0.31, 2.15) | 0.814 | 0.60 | (0.21, 1.75) | 0.296 |
| II | 0.17 | (0.54, 2.50) | 1.52 | (0.62, 3.73) | ||
| Lymphadenectomy | ||||||
| Yes | reference | reference | ||||
| No | 0.77 | (0.32, 1.85) | 0.557 | 0.49 | (0.17, 1.40) | 0.183 |
| LVSI | ||||||
| No | reference | reference | ||||
| Yes | 1.31 | (0.69, 2.51) | 0.411 | 2.46 | (1.12, 5.37) | 0.024 |
| Treatment | ||||||
| Observation | reference | reference | ||||
| Chemotherapy | 0.63 | (0.14, 2.81) | 0.306 | 0.81 | (0.17, 3.88) | 0.442 |
| Chemotherapy+radiation | 0.29 | (0.09, 0.88) | 0.34 | (0.10, 1.16) | ||
| Radiation | 0.70 | (0.29, 1.67) | 0.51 | (0.19, 1.39) | ||
| Brachytherapy | 0.70 | (0.32, 1.54) | 0.63 | (0.25, 1.56) | ||
The median overall survival was 9.80 years (95% CI 7.46 – 15.93). Age ≥ 70 years was associated with a shorter OS in the univariate and multivariable analyses. The pure UCCC had a lower rated of OS than the mixed histology group in the univariate analysis. The presence of LVSI had was associated with shorter OS in the multivariable analysis. No other clinicopathologic features were associated with OS.