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. 2019 Oct 31;15(10):e1008042. doi: 10.1371/journal.ppat.1008042

Fig 3. Displacement of the introduced WNV by locally derived genotypes.

Fig 3

(A) The WNV phylogenetic data support three main genotypes in the US: NY99, the introduced genotype; WN02, defined by the amino acid substitution E-V159A; and SW03, defined by the amino acid substitutions NS4A-A85T and NS5-K314R. The phylogeographic data from the US reveal that (B) NY99 rarely migrated past the Mississippi River, while (C) WN02 and (D) SW03 emerged in the East and spread all the way to the West Coast. WN02 and SW03 continue to cocirculate across the continent. Circle size is relative to the number of genomes that remained local. Data from specific genotypes can be visualized on Nextstrain using the “Color By: Strain” and “Filter by Lineage” functions. Live displays can be found at (A) nextstrain.org/WNV/NA?c=lineage&d=tree&f_country=USA, (B) nextstrain.org/WNV/NA?c=lineage&d=map&f_country=USA&f_lineage=NY99, (C) nextstrain.org/WNV/NA?c=lineage&d=map&f_country=USA&f_lineage=WN02, (D) nextstrain.org/WNV/NA?c=lineage&d=map&f_country=USA&f_lineage=SW03.