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. 2019 Oct 31;15(10):e1008372. doi: 10.1371/journal.pgen.1008372

Fig 1. Multiple roles of Mck1 in response to stress.

Fig 1

Upon DNA damage, Mck1, together with Dun1, antagonizes the repressor function of Crt1 via phosphorylation, which allows the derepression of RNR2/3/4 transcription. Meanwhile, Mck1 inhibits the expression of the RNR inhibitor Hug1 in a Crt1-independent manner. This mechanism allows the cell to maintain appropriate dNTPs levels according to the degree of stress. Yeast Mck1 has been shown to phosphorylate the cell cycle regulators Cdc6, Hst3, and Sld2, the calcineurin regulator Rcn1 to stimulate calcineurin signaling, Pyruvate Kinase 1 (Pyk1), and the PKA regulatory subunit Bcy1 and to have roles in meiosis, sporulation, and heat stress resistance.