. 2019 Jul 30;36(9):2193–2204. doi: 10.1007/s12325-019-01036-y

Table 1.

Studies that report diagnostic yield and safety outcomes in transbronchial lung cryobiopsy in patients with suspected interstitial lung disease including idiopathic pulmonary fibrosis

First author	Country	Year	N	Study design		No. of centres	Demographics		FVC % (mean)	Diagnostic yield (%)		IPF diagnosis (%)	Complications (%)		30-Day mortality (%)
First author	Country	Year	N	Study design		No. of centres	Age (mean)	Gender (%)	FVC % (mean)	Histological	MDT	IPF diagnosis (%)	Pneumothorax	Bleeding	30-Day mortality (%)
Babiak [22]	Germany	2009	41	Retrospective	Case series	Single	NR	NR	NR	NR	95.1	39.0	4.87	0.0	NR
Kropski [48]	USA	2013	25	Retrospective	Case series	Single	57.1	52	75.3	NR	76.0	28.0	0.0	0.0	NR
Casoni [24]	Italy	2014	69	Prospective	Observational cohort study	Single	60^a	51	81^a	93	NR	57^d	28	1.4	1.4
Fruchter [38]	Israel	2014	75	Retrospective	Case series	Single	56.2	55	NR	70	98	9.3	0.0	0.0	NR
Griff [41]	Germany	2014	52	Retrospective	Case series	Single	63^a	69	NR	79	79	25	0.0	0.0	NR
Pajares [56]	Spain	2014	39	Prospective	Randomised control trial	Single	60.3	51	78.2	74.4	51.4	0.0	7.7	56.4	NR
Hernandez-Gonzalez [42]	Spain	2015	33	Retrospective	Case series	Single	64	33	69	79	88	12	12	21	NR
Cascante [51]	Spain	2016	55	Prospective	Observational cohort study	Single	58.8	58.1	79.7	NR	87.3	32.7	14.5	10.9	0.0
Echevarria-Uraga [50]	Spain	2016	100	Retrospective	Case series	Single	63^a	66	85^a	NR	97.6	11.0	3	13	1^e
Hagmeyer [64]	Germany	2016	32	Retrospective	Case series	Single	65.4	68.8	74.6	NR	72	NR	19	78	NR
Hagmeyer [63]	Germany	2016	19	Prospective	Observational cohort study	Single	67^a	63	80^a	NR	78	NR	26	79	5.3
Ravaglia [45]	Italy	2016	297	Retrospective	Observational cohort study	Single	60^a	57.9	86.0^a	82.8	NR	NR	20.20	0.0	0.3^e
Tomassetti [49]	Italy	2016	58	Retrospective	Cross-sectional study	Single	59^a	47	82^a	NR	94.8	50.0	33	0.0	1.7^e
Almeida [44]	Portugal	2017	100	Retrospective	Case series	Single	57.15	64	90.0^a	82	NR	9.0	18.0	3.0	1.0
Bango-Alvarez [29]	Spain	2017	106	Prospective	Observational cohort study	Single	60	65	76.4	NR	86	20.8	4.7	16	NR
DiBardino [36]	USA	2017	17	Retrospective	Case series	Single	NR	NR	NR	53	82	5.9	11.8	17.6	0.0
Kronberg-White [27]	Denmark	2017	38	Retrospective	Case series	Single	61^a	58	87	84.2	97.4	26.3	26	16	0.0^e
Marçâo [39]	Portugal	2017	90	Retrospective	Case series	Single	60	58.9	85^a	73.3	70.5	8.1	22.4	5.6	NR
Sriprasart [47]	USA	2017	74	Retrospective	Case series	Single	54	49	NR	87.84	NR	14.9	6.8	4.1	4.1
Ussavarungsi [35]	USA	2017	74	Retrospective	Case series	Single	63	55	NR	51	79.7	NR	1.4	12.2	0.0
Cooley [37]	USA	2018	159	Retrospective	Observational cohort study	Single	57	46	70	69	79	6.9	11	3.8	1.9
Hagmeyer [72]	Germany	2018	42	Prospective	Observational cohort study	Single	66	57	82	NR	76.2	NR	12	0	2
Lentz [34]	USA	2018	104	Retrospective	Case series	Single	58.2	55.8	70.2	44.2	68.3	21.2	2.9	3.8	NR
Cho [46]	USA	2019	40	Retrospective	Case series	Single	57.2	70	68.51	85	NR	2.5	0	10	0
Kuse [40]	Japan	2019	38	Retrospective	Case series	Single	71^b	68^b	NR	74	92	7.9	0.0	0.0	0.0^e
Ravaglia [54]	Italy	2019	699	Retrospective	Observational cohort study	Single	61^a	59.1	85.4	87.8	90.1	35.1	19.2	8.3	0.4
Romagnoli [61]	France/Italy	2019	21	Prospective	Single group assignment study	Two	65^a	48	80.05	38^c	48	42.9	9.5	0.0	NR
Samitas [43]	Greece	2019	50	Retrospective	Case series	Single	61	58	69.7	80	76	6.0	10	24	NR
Wäscher [62]	Germany	2019	109	Retrospective	Case series	Single	64^a	66	77^a	73.4	83.5	8.3	11.9	28.4	0.0

IPF idiopathic pulmonary fibrosis, MDT multidisciplinary team, NR not reported

^aReported as median

^bMixed cohort of IPF and lung malignancy patients

^cDiagnostic accuracy

^dIncludes possible IPF

^eDid not specify 30-day mortality