Table 2.

Proteins (and their genes) found in both epithelium and stroma and their regulation in keratoconus

Up-regulated		Down-regulated
Protein	Gene [reference]	Protein	Gene [reference]
Increased epithelial and stromal		Decreased epithelial and stromal
Keratin type I cytoskeletal 14 (KRT14)	KRT14 [14, 44]	Transketolase	TKT [14, 44]
Keratin type I cytoskeletal 16 (KRT16)	KRT16 [14, 44]	Pyruvate kinase	PKLR [14, 44]
Tubulin beta chain (TUBB)	TUBB [14, 44]	Stratifin (14-3-3 sigma isoform)	SFN [14, 44]
Lamin-A/C (LMNA)	LMNA [14, 44]	Phosphoglycerate kinase 1 (PGK 1)	PGK1 [14, 44]
S100 calcium-binding protein A4 (S100A4)	S100A4 [14, 44]	NAD (P)H dehydrogenase (quinone) 1	NQO1 [14, 44]
Heat shock cognate 71 kDa protein (HSPA8)	HSPA8 [14, 44]