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. 2019 Jun 25;36(9):2475–2486. doi: 10.1007/s12325-019-01012-6

Table 1.

Attributes and levels

Attributes Levels
Efficacy
 Cure rate 95%; 97%; 100%
Convenience
 Once-daily tablet count and packaging

1 tablet from a prescription bottle

1 tablet in a single-dose blister pack

3 tablets in a single-dose blister pack

 Duration of treatment (weeks) 8; 12; 16; 24
 Office visits for HCV treatment (all patients required to have 1 visit for treatment initiation and 1 visit for post-treatment viral evaluation)

Simplified monitoring during HCV treatment (e.g., telephone check-in by doctor or nurse)

One additional office visit during HCV treatment

Two additional office visits during HCV treatment

Co-therapy management
 Modification of concurrent statin usea

No modification to a statin

Temporarily reduce dose of a statin

Temporarily stop taking a statin

Switch to a different medication

 Modification of concurrent PPI useb

No modification to a PPI

Temporarily reduce dose or modify timing of taking a PPI

Temporarily stop taking a PPI

Switch to a different medication

Mild common side effects
 Risk of diarrhea 5%; 15%; 25%
 Risk of headache 5%; 15%; 25%; 35%
 Risk of nausea 5%; 15%; 25%

HCV hepatitis C virus, PPI proton pump inhibitor

aThe levels “temporarily reduce dose of a statin” and “temporarily stop taking a statin” were pooled in the analysis, as they both reflect similar, temporary modifications of use

bThe levels “temporarily reduce dose or modify timing of taking a PPI” and “temporarily stop taking a PPI” were pooled in the analysis, as they both reflect similar temporary modifications of use