Table 1.
Attributes and levels
Attributes | Levels |
---|---|
Efficacy | |
Cure rate | 95%; 97%; 100% |
Convenience | |
Once-daily tablet count and packaging |
1 tablet from a prescription bottle 1 tablet in a single-dose blister pack 3 tablets in a single-dose blister pack |
Duration of treatment (weeks) | 8; 12; 16; 24 |
Office visits for HCV treatment (all patients required to have 1 visit for treatment initiation and 1 visit for post-treatment viral evaluation) |
Simplified monitoring during HCV treatment (e.g., telephone check-in by doctor or nurse) One additional office visit during HCV treatment Two additional office visits during HCV treatment |
Co-therapy management | |
Modification of concurrent statin usea |
No modification to a statin Temporarily reduce dose of a statin Temporarily stop taking a statin Switch to a different medication |
Modification of concurrent PPI useb |
No modification to a PPI Temporarily reduce dose or modify timing of taking a PPI Temporarily stop taking a PPI Switch to a different medication |
Mild common side effects | |
Risk of diarrhea | 5%; 15%; 25% |
Risk of headache | 5%; 15%; 25%; 35% |
Risk of nausea | 5%; 15%; 25% |
HCV hepatitis C virus, PPI proton pump inhibitor
aThe levels “temporarily reduce dose of a statin” and “temporarily stop taking a statin” were pooled in the analysis, as they both reflect similar, temporary modifications of use
bThe levels “temporarily reduce dose or modify timing of taking a PPI” and “temporarily stop taking a PPI” were pooled in the analysis, as they both reflect similar temporary modifications of use