Table 4.
Statin intolerance symptom severity and bothersomeness ratings
| Symptoms | All patients (n = 65) | |||
|---|---|---|---|---|
| Symptom severity | Symptom bothersomeness | |||
| n | Mean score (SD) [range] | n | Mean score (SD) [range] | |
| Non-muscle-related pain and discomfort | ||||
| Arthritis and bone symptoms | ||||
| Bone or joint ache | 10 | 7.7 (0.9) [6–9] | 4 | 7.8 (2.1) [6–10] |
| Bone or joint pain | 3 | 5.7 (2.9) [4–9] | 26 | 7.7 (2.1) [3–10] |
| Stiff or cracking joints | 3 | 6.7 (3.5) [3–10] | 2 | 10.0 (0) [10] |
| Soreness | 5 | 7.8 (2.0) [6–10] | 7 | 7.1 (3.0) [3–10] |
| Tenderness | 3 | 7.0 (1.7) [5–8] | 7 | 7.7 (1.3) [6–10] |
| Bone or joint weakness | ||||
| Joint weakness | 0 | NA | 1 | 8.0 |
| Burning and stinging | ||||
| Burning | 2 | 8.5 (2.1) [7–10] | 1 | 9.0 |
| Stinging | 0 | NA | 1 | 8.0 |
| Headache | 4 | 7.3 (2.1) [5–10] | 5 | 6.2 (2.2) [5–10] |
| Non-muscle neck or back pain | 0 | NA | 6 | 8.2 (3.0) [3–10] |
| Non-muscle pain or discomfort | 21 | 7.4 (2.0) [2–10] | 14 | 7.6 (1.6) [5–10] |
| Muscle-related pain or discomfort | ||||
| Muscle ache | 23 | 7.4 (2.1) [3–10] | 28 | 6.4 (2.0) [2–10] |
| Muscle burning | 0 | NA | 1 | 7.0 |
| Muscle cramps | 25 | 7.4 (2.2) [2–10] | 26 | 7.0 (2.5) [2–10] |
| Muscle tears | 1 | 10.0 | 2 | 9.0 (1.4) [8–10] |
| Soreness and tenderness | ||||
| Soreness | 12 | 8.1 (1.8) [5–10] | 14 | 6.8 (1.9) [4–10] |
| Tenderness | 8 | 8.3 (1.7) [5–10] | 7 | 7.0 (1.9) [4–10] |
| Muscle pain or discomfort | 39 | 7.2 (2.3) [3–10] | 26 | 7.1 (2.4) [1–10] |
| Non-pain muscle-related symptoms | ||||
| Muscle weakness | ||||
| Muscle fatigue | 13 | 7.7 (2.6) [1–10] | 13 | 7.1 (2.2) [4–10] |
| Muscle heaviness | 18 | 7.0 (2.5) [1–10] | 18 | 6.9 (2.2) [2–10] |
| Muscle weakness | 19 | 7.4 (1.9) [5–10] | 26 | 7.0 (2.0) [2–10] |
| Muscle stiffness | 19 | 7.1 (2.5) [3–10] | 28 | 6.4 (2.2) [1–10] |
| Muscle tingling | 1 | 5.0 | 5 | 6.2 (1.3) [5–8] |
| Muscle loss | ||||
| Lack of tone | 1 | 5.0 | 1 | 7.0 |
| Muscle loss | 1 | 3.5 | 4 | 6.0 (1.8) [4–8] |
| Muscle wasting | 0 | NA | 1 | 10.0 |
| Muscle lump | 0 | NA | 1 | 6.0 |
| Warm/heat in upper leg; blocking spine chest part | 2 | 8.8 (1.8) [7.5–10] | 2 | 8.5 (2.1) [7–10] |
| Gastrointestinal symptoms | ||||
| Abdominal discomfort | ||||
| Poor digestion | 1 | 8.0 | 1 | 8.0 |
| Abdominal pain or cramps | 6 | 8.0 (1.4) [6–10] | 8 | 6.4 (2.3) [3–9] |
| Acid reflux | 1 | 10.0 | 1 | 10.0 |
| Bloating | 2 | 7.5 (0.7) [7–8] | 1 | 7.0 |
| Constipation | 2 | 5.0 (2.8) [3–7] | 3 | 8.0 (2.0) [6–10] |
| Diarrhea | 9 | 7.3 (1.9) [4–9] | 11 | 6.1 (2.8) [1–10] |
| Nausea | 5 | 7.2 (2.6) [4–10] | 6 | 6.7 (3.4) [2–10] |
| Stool changes | 0 | NA | 1 | 7.0 |
| Vomiting | 4 | 6.8 (2.8) [4–10] | 2 | 7.5 (3.5) [5–10] |
| Cardiovascular symptoms | ||||
| Difficulty breathing | 0 | NA | 4 | 9.3 (1.0) [8–10] |
| Heart palpitations | 1 | 8.5 | 2 | 7.0 (2.8) [5–9] |
| Increased heart rate | 1 | 5.0 | 0 | NA |
| Cold-like symptoms | ||||
| Chills | 2 | 7.0 (1.4) [6–8] | 3 | 5.3 (2.1) [3–7] |
| Dizziness | ||||
| Dizziness | 2 | 8.5 (0.7) [8–9] | 2 | 9.0 (1.4) [8–10] |
| Feels faint | 2 | 9.5 (0.7) [9–10] | 1 | 10.0 |
| Feels sick or poorly | 6 | 6.8 (1.8) [5–10] | 8 | 6.9 (2.5) [2–10] |
| Feels hot | 2 | 7.0 (1.4) [6–8] | 2 | 7.5 (2.1) [6–9] |
| Runny or stuffy nose | 3 | 8.7 (1.2) [8–10] | 4 | 5.3 (3.0) [2–9] |
| Sneezing | 1 | 8.0 | 4 | 4.0 (0.8) [3–5] |
| Throat symptoms | ||||
| Sore throat | 5 | 6.5 (2.8) [3–9.5] | 8 | 5.5 (2.7) [1–9] |
| Mood changes due to medication | ||||
| Anxiety | ||||
| Anxiety | 12 | 7.8 (2.8) [1–10] | 12 | 8.4 (1.2) [6–10] |
| Nervous | 0 | NA | 1 | 8.0 |
| Depression | ||||
| Depression | 6 | 9.2 (1.3) [7–10] | 7 | 7.9 (1.7) [5–10] |
| Low mood | 1 | 5.0 | 1 | 6.0 |
| Sadness | 2 | 9.5 (0.7) [9–10] | 3 | 7.7 (1.5) [6–9] |
| Mood changes | 0 | NA | 1 | 7.0 |
| Hostility or agitation | 5 | 8.4 (2.2) [6–10] | 6 | 6.8 (2.8) [3–10] |
| Cognitive and memory problems | ||||
| Cognitive symptoms | ||||
| Fuzzy thoughts | 0 | NA | 1 | 9.0 |
| Difficulty concentrating | 2 | 8.5 (2.1) [7–10] | 6 | 8.8 (1.2) [7–10] |
| Memory problems | ||||
| Amnesia | 2 | 10.0 (0.0) [10] | 0 | NA |
| Memory problems | 10 | 7.2 (2.3) [4–10] | 10 | 8.2 (2.1) [4–10] |
| Fatigue-related symptoms | ||||
| Fatigue | 0 | NA | 15 | 7.1 (1.9) [3–10] |
| Exhaustion | 17 | 7.3 (1.8) [5–10] | 22 | 7.5 (2.0) [2–10] |
| Lack of energy | 24 | 7.1 (2.2) [3–10] | 26 | 7.4 (2.1) [2–10] |
| Tiredness | 24 | 6.7 (2.3) [3–10] | 21 | 7.3 (2.0) [5–10] |
| Sensory and systems problems | ||||
| Skin and hair symptoms | ||||
| Bruising | 1 | 2.0 | 1 | 6.0 |
| Eczema | 0 | NA | 1 | 6.0 |
| Hair loss | 2 | 9.0 (0.0) [9] | 2 | 10.0 (0.0) [10] |
| Rash | 2 | 8.5 (2.1) [7–10] | 2 | 10.0 (0.0) [10] |
| Sensitive skin | 0 | NA | 2 | 9.5 (0.7) [9–10] |
| Skin ulcers | 1 | 6.0 | 1 | 10.0 |
| Additional symptoms | ||||
| Kidney problems | ||||
| Frequent urination | 0 | NA | 2 | 7.0 (4.2) [4–10] |
| Liver problems | 1 | 8.0 | 2 | 7.0 (4.2) [4–10] |
| Sweating | 0 | NA | 2 | 9.0 (1.4) [8–10] |
| Swelling or inflammation | ||||
| Swelling | 2 | 9.5 (0.7) [9–10] | 4 | 8.3 (1.7) [6–10] |
| Weight-related symptoms | ||||
| Fat loss | 0 | NA | 1 | 0.0 |
| Weight gain | 1 | 10.0 | 1 | 10.0 |
n number of patients rating symptom, NA not applicable, SD standard deviation