Table III.
Moderated Mediation Analyses Testing Change in Depression Symptoms During the Intervention Period as an Intervening Variable Underlying Intervention’s Effects on Body Composition and Insulin Outcomes, Moderated by Baseline Depression Symptoms
| Path a | Moderation of Path a (a3) | Path b | Index of moderated mediation (a3b) | Direct effect (c’) | |
|---|---|---|---|---|---|
| Outcome | B, SE (95% CI) | ΔR2 (p) | B, SE (95% CI) | B (95% CI) | B, SE (95% CI) |
| BMI (kg/m2) | 4.37, 3.76 (−3.08, −11.84) | 0.01 (0.10) | 0.05, 0.02 (0.01, 0.09) | −0.01 (−0.03, 0.00) | −0.30, 0.28 (−0.86, 0.26) |
| %Adiposity | −4.59, 3.73 (−2.80, −11.98) | 0.01 (0.08) | 0.001, 0.01 (0.0003, 0.002) | 0.00 (0.00, 0.00) | 0.00, 0.01 (−0.01, 0.01) |
| WBISI | 5.65, 3.66 (−1.62, −12.91) | 0.02 (0.04) | −0.03, 0.12 (−0.05, -0.0003) | 0.01 (0.00, 0.02) | 0.03, 0.18 (−0.33, 0.38) |
| HOMA-IR | 5.70, 3.72 (−1.67, −13.06) | 0.02 (0.04) | 0.06, 0.03 (0.01, 0.12) | −0.02 (−0.06, 0.00) | 0.12, 0.40 (−0.68, 0.92) |
| Fasting insulin | 5.64, 3.72 (−1.73, −13.01) | 0.02 (0.046) | 0.28, 0.12 (0.04, 0.51) | −0.08 (−0.24, −0.002) | 0.27, 1.69 (−3.09, 3.63) |
| Two-hour insulin | 5.30, 3.70 (−2.03, −12.64) | 0.02 (0.045) | −0.13. 0.73 (−1.58, 1.32) | 0.04 (−0.57, 0.46) | −1.90, 10.75 (−23.20, −19.40) |
Note. BMI = body mass index; HOMA-IR = homeostasis model assessment of insulin resistance, with higher values representing greater insulin resistance and lower values little to no insulin resistance; WBISI = whole body insulin sensitivity index, with higher values reflecting better insulin sensitivity and lower values poorer insulin sensitivity. Path c indicates the total effect from intervention to outcome; Path a indicates the directional path from intervention to the mediator; Path b indicates the directional path from the mediator to the outcome; Path ab indicates the indirect path from intervention to outcome indirectly through the mediator; Path c’ indicates the direct path from intervention to outcome independently of the mediator. Significant paths are presented in bolded font.