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. Author manuscript; available in PMC: 2020 Feb 13.
Published in final edited form as: Oncogene. 2019 Aug 13;38(44):7017–7034. doi: 10.1038/s41388-019-0923-2

Figure 2. LSD1 and GATA3 co-regulate breast cancer-related target genes.

Figure 2.

(a) Hierarchical clustering of genes altered by LSD1 knockdown or GATA3 knockdown in MCF7 cells.

(b) Numbers of genes altered by either LSD1 knockdown or GATA3 knockdown in MCF7 cells. A set of 443 genes are significantly affected by both LSD1 and GATA3 knockdown.

(c-d) Common gene sets downregulated (c) or upregulated (d) in MCF7 cells upon either LSD1 or GATA3 knockdown.

(e) Western blotting analysis showing downregulation of E-cadherin, vinculin and α-catenin in MCF7 cells upon either LSD1 or GATA3 knockdown.

(f) Integrated analysis of ChIP-seq data for GATA3 and LSD1 in MCF7 cells showing 519 peaks in common.