TABLE 1.

Proteins differentially abundant in LCMV-infected HeLa cells identified by MALDI-TOF tandem mass spectrometry.

Spot ID	UniProt ID	Gene name	Protein name	Mascot score	Number of peptides/SC (%)	Av. ratio HeLa-MX/HeLa
3	P14625	HSP90B1	Endoplasmin	133.6	4/4.5	−2.09
5	P09382	LGALS1	Galectin-1	334.8	4/34.8	1.79
6	P29373	CRABP2	Cellular retinoic acid-binding protein 2	255.2	4/30.4	Only HeLa
7	P32119	PRDX2	Peroxiredoxin-2	511.0	9/31.8	−1.5
8	P07741	APRT	Adenine phosphoribosyltransferase	489.7	7/38.9	−1.82
9	Q13162	PRDX4	Peroxiredoxin-4	559.9	9/29.2	−2.08
10	P30041	PRDX6	Peroxiredoxin-6	209.1	5/21.9	−1.71
11	Q15185	PTGES3	Prostaglandin E synthase 3	381.9	7/20.0	Only HeLa
12	P61978	HNRNPK	Heterogeneous nuclear ribonucleoprotein K	201.8	3/7.1	2.41
13	P61978	HNRNPK	Heterogeneous nuclear ribonucleoprotein K	88.7	4/8.4	1.7
15	P10809	HSPD1	60 kDa heat shock protein, mitochondrial	617.7	12/22.7	−2.32
16	P10809	HSPD1	60 kDa heat shock protein, mitochondrial	162.0	5/8.7	−2.08
17	Q01581	HMGCS1	Hydroxymethylglutaryl-CoA synthase	92.9	2/4.4	Only HeLa-MX
18	Q02790	FKBP4	Peptidyl-prolyl cis-trans isomerase FKBP4	311.7	8/17.0	−1.61
19	P05787	KRT8	Keratin, type II cytoskeletal 8	218.6	4/9.5	3.07
20	P05787	KRT8	Keratin, type II cytoskeletal 8	247.5	7/12.2	−1.76
21	P60842	EIF4A1	Eukaryotic initiation factor 4A-I	163.0	5/12.8	Only HeLa
22	Q9Y2T3	GDA	Guanine deaminase	67.8	2/4.6	Only HeLa-MX
24	P40121	CAPG	Macrophage-capping protein	122.9	3/11.5	1.62
25	P20073	ANXA7	Annexin A7	98.9	4/4.5	Only HeLa-MX
26	P50395	GDI2	Rab GDP dissociation inhibitor beta	320.7	6/17.3	Only HeLa-MX
27	B7Z2S5	TXNRD1	Thioredoxin reductase 1, cytoplasmic	65.1	2/4.6	1.61
31	P06733	ENO1	Alpha-enolase	158.2	4/16.1	1.92
32	P62826	RAN	GTP-binding nuclear protein Ran	217.1	4/15.7	−1.54

Positive ratios indicate proteins accumulated in virus-infected cells, negative ratios show proteins more abundant in mock-inoculated controls. SC, sequence coverage.