Table 2.
Some estrogen regulated miRNAs and their effect on myocardium and cardiac vascular system cells.
| miRNA | Vascular cells | Functions | Targets | References |
|---|---|---|---|---|
| miR-126-3p | Endothelial cells | Migration Angiogenesis |
Spred1 | (205) |
| miR-221&-222 | Endothelial cells | Inflammation | ETS-1 | (206) |
| miR-106b | Endothelial cells VSMC | Apoptosis | PTEN | (207) |
| miR-143/-145 | VSMC | Proliferation Contraction |
ACE | (208) |
| miR-30 | Endothelial cells VSMC | Angiogenesis Apoptosis Inflammation |
Ang2 | (209) |
| miR-203 | VSMC | Proliferation | SRC, ERK | (210) |
| miR-144 | Endothelial cells VSMC |
Inflammation Metabolism |
COX2 Rac1 ABCA1 |
(211) (212) (213) |
| miR-146a | Endothelial cells | Inflammation Senescence |
TRAF6, IRAK1 NOX4 |
(214) (215) |
| miR-21 | VSMC Fibroblast |
Inflammation Proliferation |
PPARα, Spry1 NF1B,CDC25A |
(216) (217) (218) |
| miR-125 | Endothelial cells | Angiogenesis | RTEF-1, VEGF | (219) |
| miR-34 | Endothelial cells | Senescence Inflammation |
SIRT-1 | (220, 221) |