Comparison 2.

Azathioprine versus placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Adverse effects	5		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
1.1 Gastrointestinal	4	633	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.80 [1.93, 7.46]
1.2 Cutaneous rash	4	658	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.14 [0.96, 4.77]
1.3 Viral or bacterial infections	3	459	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.49 [0.64, 3.47]
1.4 Abnormal liver enzymes	3	593	Peto Odds Ratio (Peto, Fixed, 95% CI)	4.49 [2.10, 9.60]
1.5 Leucopenia (<3000 WBC/mm3)	4	513	Peto Odds Ratio (Peto, Fixed, 95% CI)	8.58 [4.78, 15.39]
1.6 Anaemia	2	539	Peto Odds Ratio (Peto, Fixed, 95% CI)	5.19 [1.49, 18.08]
1.7 Total malignancy (3 years)	2	419	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.93 [0.41, 21.00]