Comparison 1.

Subjective

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Improvement	1	94	Peto Odds Ratio (Peto, Fixed, 95% CI)	15.09 [6.42, 35.48]
1.1 low	1	19	Peto Odds Ratio (Peto, Fixed, 95% CI)	9.86 [1.67, 58.20]
1.2 intermeidiate	1	19	Peto Odds Ratio (Peto, Fixed, 95% CI)	9.86 [1.67, 58.20]
1.3 high	1	18	Peto Odds Ratio (Peto, Fixed, 95% CI)	29.96 [4.92, 182.55]
1.4 any	1	38	Peto Odds Ratio (Peto, Fixed, 95% CI)	17.35 [3.76, 80.13]
2 Improvement substantial	1	94	Peto Odds Ratio (Peto, Fixed, 95% CI)	11.69 [4.96, 27.56]
2.1 low	1	19	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.32 [1.19, 45.04]
2.2 intermeidiate	1	19	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.32 [1.19, 45.04]
2.3 high	1	18	Peto Odds Ratio (Peto, Fixed, 95% CI)	29.96 [4.92, 182.55]
2.4 any	1	38	Peto Odds Ratio (Peto, Fixed, 95% CI)	11.57 [2.60, 51.59]
3 Unchanged or worse	1	94	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.07 [0.03, 0.16]
3.1 low	1	19	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.10 [0.02, 0.60]
3.2 intermeidiate	1	19	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.10 [0.02, 0.60]
3.3 high	1	18	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.03 [0.01, 0.20]
3.4 any	1	38	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.06 [0.01, 0.27]