Figure 7.

The effective Young's modulus E_p of an elastic spherical shell having the same compliance as that of a typical vehicle-treated and genipin-treated eye from a young adult C57BL/6 mouse calculated using the Step Response Method. E_p was determined based on Equations (17) and (3), assuming a radius R = 1.6 mm and thickness h = 0.04 mm (defined at 13 mmHg). Note that R and h change as a function of pressure due to the changing volume of the eye and constraints of incompressibility applied to the corneoscleral shell. Values of ϕ_r and γ were defined based on values reported in Table 1. Shaded regions represent uncertainty due to 95% confidence intervals on ϕ_r. Dashed vertical line represents the reference pressure, P_r, defined to be 13 mmHg.