Table 1.

Characteristics of all recruited patients.

Study group	Characteristics	Patients
		pSS without NMOSD	pSS with NMOSD	NMOSD
Screening group
	Total number	8	4	NA
	Sex ratio (F:M)	7:1	4:0
	Average of age disease onset (years)	47.6 ± 15.7	32.5 ± 8.4
	Average duration (months, median)	120	10
	Dry mouth	8 (100)	4 (100)
	Dry eyes	8 (100)	3 (75)
	Objective xerostomia	8 (100)	4 (100)
	Postive ocular tests	8 (100)	3 (75)
	Positive salivary gland biopsy	8 (100)	4 (100)
	ANA positive	8 (100)	3 (75)
	Anti-Ro/SSA positive	8 (100)	4 (100)
	Anti-La/SSB positive	6 (75)	1 (25)
Verification group for CFH
	Total number	22	22	NA
	Sex ratio (F:M)	21:1	8:3
	Average of age disease onset (years)	50 ± 10.3	40 ± 11.2
	Average duration (months, median)	48	36
	Dry mouth	19 (86.3)	18 (81.2)
	Dry eyes	17 (77.3)	16 (72.3)
	Objective xerostomia	20 (90.1)	19 (86.4)
	Postive ocular tests	20 (90.1)	19 (86.4)
	Positive salivary gland biopsy	14/16 (87.5)	15/18 (83.3)
	ANA positive	22 (100)	22 (100)
	Anti-Ro/SSA positive	22 (100)	22 (100)
	Anti-La/SSB positive	9 (40.9)	6 (27.3)
Verification group for clusterin
	Total number	26	22	30
	Sex ratio (F:M)	11:2	8:3	23:7
	Average of age disease onset (years)	47 ± 10.3	40 ± 11.2	40 ± 14.6
	Average duration (months, median)	46	36	38
	Dry mouth	23 (88.5)	18 (81.2)	0 (0)
	Dry eyes	19 (73.1)	16 (72.3)	0 (0)
	Objective xerostomia	24 (92.3)	19 (86.4)	NA
	Postive ocular tests	23 (88.5)	19 (86.4)	NA
	Positive salivary gland biopsy	17/19 (89.5)	15/18 (83.3)	NA
	ANA positive	26 (100)	22 (100)	5 (16.7)
	Anti-Ro/SSA positive	26 (100)	22 (100)	0 (0)
	Anti-La/SSB positive	10 (38.5)	6 (27.3)	0 (0)

pSS, primary Sjögren's syndrome; NMOSD, Neuromyelitis optica spectrum disorder; CFH, complement factor H.