Table 2.

Different features affecting the development of RNAi-based products: Transformative vs. Non-transformative methods.

Feature	Strategy
	Transformative	Non-transformative¹
Development time	High	Low²
Development costs	High	Low
Feasibility according to culture	Unviable for some plant species	Viable for all cultures¹
Delivery of sRNA	Continuous	Transient
Feasibility according to the pest	Most pests can be targeted due to continuous dsRNA supply feature	Not all pests can be targeted due to recalcitrant features
Development of resistance	High	Low
Regulatory process	Extensive	Simple
Acceptance by consumers	Low	High

¹Non-transformative delivery approaches: foliar application, trunk injection, and irrigation water among others; ²Non-transforative strategy compared to transformative strategy.