Comparison 3.

Higher dose of standard interferon versus lower dose

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure of virological response: end of treatment	2	60	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.59, 1.05]
2 Failure of virological response: six months after completion of treatment	2	60	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.68, 1.07]
3 Failure of biochemical response: end of treatment	2	60	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.75, 1.33]
4 Failure of biochemical response: Six months after completion of treatment	2	60	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.84, 1.43]