Comparison 2.

PD+/‐AGORAPHOBIA: Psychotherapy+Antidepressant vs Psychotherapy alone

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	6	366	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.85, 1.50]
1.1 Behaviour therapy	2	59	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.11, 7.30]
1.2 Cognitive‐behaviour therapy	4	307	Risk Ratio (M‐H, Random, 95% CI)	1.09 [0.90, 1.31]
2 Remission at 2‐4 months	4	282	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.97, 1.45]
2.1 Behaviour therapy	2	59	Risk Ratio (M‐H, Random, 95% CI)	0.70 [0.16, 3.15]
2.2 Cognitive‐behaviour therapy	2	223	Risk Ratio (M‐H, Random, 95% CI)	1.22 [0.98, 1.52]
3 Global severity at 2‐4 months	3	238	Std. Mean Difference (IV, Random, 95% CI)	‐0.31 [‐0.63, 0.02]
3.1 Behaviour therapy	1	37	Std. Mean Difference (IV, Random, 95% CI)	‐0.68 [‐1.34, ‐0.01]
3.2 Cognitive‐behaviour therapy	2	201	Std. Mean Difference (IV, Random, 95% CI)	‐0.22 [‐0.56, 0.13]
4 Frequency of panic attacks at 2‐4 months	4	122	Std. Mean Difference (IV, Random, 95% CI)	0.02 [‐0.45, 0.49]
4.1 Behaviour therapy	2	48	Std. Mean Difference (IV, Random, 95% CI)	‐0.01 [‐1.30, 1.28]
4.2 Cognitive‐behaviour therapy	2	74	Std. Mean Difference (IV, Random, 95% CI)	0.13 [‐0.33, 0.58]
5 Phobic avoidance at 2‐4 months	4	150	Std. Mean Difference (IV, Random, 95% CI)	‐0.19 [‐0.73, 0.35]
5.1 Behaviour therapy	2	51	Std. Mean Difference (IV, Random, 95% CI)	‐0.27 [‐1.77, 1.22]
5.2 Cognitive‐behaviour therapy	2	99	Std. Mean Difference (IV, Random, 95% CI)	‐0.05 [‐0.44, 0.35]
6 General anxiety at 2‐4 months	4	144	Std. Mean Difference (IV, Random, 95% CI)	‐0.17 [‐0.69, 0.35]
6.1 Behaviour therapy	2	51	Std. Mean Difference (IV, Random, 95% CI)	‐0.55 [‐1.44, 0.34]
6.2 Cognitive‐behaviour therapy	2	93	Std. Mean Difference (IV, Random, 95% CI)	0.09 [‐0.32, 0.49]
7 Depression at 2‐4 months	4	125	Std. Mean Difference (IV, Random, 95% CI)	‐0.51 [‐1.15, 0.12]
7.1 Behaviour therapy	2	51	Std. Mean Difference (IV, Random, 95% CI)	‐0.94 [‐1.62, ‐0.25]
7.2 Cognitive‐behaviour therapy	2	74	Std. Mean Difference (IV, Random, 95% CI)	‐0.31 [‐1.12, 0.49]
8 Social malfunctioning at 2‐4 months	1	59	Std. Mean Difference (IV, Random, 95% CI)	‐0.18 [‐0.69, 0.33]
8.1 Behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
8.2 Cognitive‐behaviour therapy	1	59	Std. Mean Difference (IV, Random, 95% CI)	‐0.18 [‐0.69, 0.33]
9 Dropouts for any reason within 2‐4 months	5	322	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.72, 1.59]
9.1 Behaviour therapy	2	59	Risk Ratio (M‐H, Random, 95% CI)	1.46 [0.40, 5.38]
9.2 Cognitive‐behaviour therapy	3	263	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.65, 1.72]
10 Dropouts due to side effects within 2‐4 months	4	308	Risk Ratio (M‐H, Random, 95% CI)	7.46 [1.73, 32.26]
10.1 Behaviour therapy	1	45	Risk Ratio (M‐H, Random, 95% CI)	4.4 [0.22, 86.78]
10.2 Cognitive‐behaviour therapy	3	263	Risk Ratio (M‐H, Random, 95% CI)	8.82 [1.64, 47.37]
11 Response/remission on continued treatment	1	142	Risk Ratio (M‐H, Random, 95% CI)	1.37 [0.98, 1.92]
11.1 Behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
11.2 Cognitive‐behaviour therapy	1	142	Risk Ratio (M‐H, Random, 95% CI)	1.37 [0.98, 1.92]
12 GlobalAvoidance/Panic on continued treatment	1	142	Std. Mean Difference (IV, Random, 95% CI)	‐0.46 [‐0.80, ‐0.13]
12.1 Behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
12.2 Cognitive‐behaviour therapy	1	142	Std. Mean Difference (IV, Random, 95% CI)	‐0.46 [‐0.80, ‐0.13]
13 Dropouts for any reason on continued treatment	1	142	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.21, 2.21]
13.1 Behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
13.2 Cognitive‐behaviour therapy	1	142	Risk Ratio (M‐H, Random, 95% CI)	0.68 [0.21, 2.21]
14 Response/remission 6‐24 months after treatment discontinuation	4	272	Risk Ratio (M‐H, Random, 95% CI)	0.97 [0.71, 1.33]
14.1 Behaviour therapy	2	59	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.54, 1.60]
14.2 Cognitive‐behaviour therapy	2	213	Risk Ratio (M‐H, Random, 95% CI)	0.99 [0.68, 1.45]
15 Global/Avoidance/Panic 6‐24 months after treatment discontinuation	2	167	Std. Mean Difference (IV, Random, 95% CI)	0.09 [‐0.21, 0.40]
15.1 Behaviour therapy	1	35	Std. Mean Difference (IV, Random, 95% CI)	‐0.05 [‐0.71, 0.61]
15.2 Cognitive‐behaviour therapy	1	132	Std. Mean Difference (IV, Random, 95% CI)	0.13 [‐0.21, 0.47]