Comparison 3.

PD+/‐AGORAPHOBIA: Psychotherapy+Antidepressant vs Psychotherapy+Placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	17	1032	Risk Ratio (M‐H, Random, 95% CI)	1.17 [1.04, 1.32]
1.1 Behaviour therapy	10	527	Risk Ratio (M‐H, Random, 95% CI)	1.24 [1.03, 1.48]
1.2 Cognitive‐behaviour therapy	7	505	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.93, 1.47]
2 Remission at 2‐4 months	15	952	Risk Ratio (M‐H, Random, 95% CI)	1.30 [1.10, 1.54]
2.1 Behaviour therapy	8	447	Risk Ratio (M‐H, Random, 95% CI)	1.45 [1.10, 1.91]
2.2 Cognitive‐behaviour therapy	7	505	Risk Ratio (M‐H, Random, 95% CI)	1.26 [0.99, 1.60]
3 Global severity at 2‐4 months	8	477	Std. Mean Difference (IV, Random, 95% CI)	‐0.45 [‐0.63, ‐0.26]
3.1 Behaviour therapy	5	221	Std. Mean Difference (IV, Random, 95% CI)	‐0.61 [‐0.88, ‐0.33]
3.2 Cognitive‐behaviour therapy	3	256	Std. Mean Difference (IV, Random, 95% CI)	‐0.35 [‐0.69, ‐0.00]
4 Frequency of panic attacks at 2‐4 months	9	393	Std. Mean Difference (IV, Random, 95% CI)	‐0.06 [‐0.27, 0.15]
4.1 Behaviour therapy	7	248	Std. Mean Difference (IV, Random, 95% CI)	0.07 [‐0.19, 0.32]
4.2 Cognitive‐behaviour therapy	2	145	Std. Mean Difference (IV, Random, 95% CI)	‐0.29 [‐0.61, 0.04]
5 Phobic avoidance at 2‐4 months	15	582	Std. Mean Difference (IV, Random, 95% CI)	‐0.35 [‐0.54, ‐0.15]
5.1 Behaviour therapy	10	364	Std. Mean Difference (IV, Random, 95% CI)	‐0.42 [‐0.72, ‐0.11]
5.2 Cognitive‐behaviour therapy	5	218	Std. Mean Difference (IV, Random, 95% CI)	‐0.26 [‐0.53, 0.01]
6 General anxiety at 2‐4 months	13	595	Std. Mean Difference (IV, Random, 95% CI)	‐0.47 [‐0.65, ‐0.29]
6.1 Behaviour therapy	7	270	Std. Mean Difference (IV, Random, 95% CI)	‐0.67 [‐0.96, ‐0.38]
6.2 Cognitive‐behaviour therapy	6	325	Std. Mean Difference (IV, Random, 95% CI)	‐0.32 [‐0.54, ‐0.09]
7 Depression at 2‐4 months	12	436	Std. Mean Difference (IV, Random, 95% CI)	‐0.40 [‐0.60, ‐0.19]
7.1 Behaviour therapy	9	318	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.68, ‐0.13]
7.2 Cognitive‐behaviour therapy	3	118	Std. Mean Difference (IV, Random, 95% CI)	‐0.38 [‐0.76, ‐0.01]
8 Social malfunctioning at 2‐4 months	10	374	Std. Mean Difference (IV, Random, 95% CI)	‐0.37 [‐0.65, ‐0.10]
8.1 Behaviour therapy	7	260	Std. Mean Difference (IV, Random, 95% CI)	‐0.55 [‐0.84, ‐0.26]
8.2 Cognitive‐behaviour therapy	3	114	Std. Mean Difference (IV, Random, 95% CI)	‐0.04 [‐0.41, 0.33]
9 Dropouts for any reason within 2‐4 months	15	950	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.94, 1.50]
9.1 Behaviour therapy	8	445	Risk Ratio (M‐H, Random, 95% CI)	1.18 [0.88, 1.58]
9.2 Cognitive‐behaviour therapy	7	505	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.81, 1.78]
10 Dropouts due to side effects within 2‐4 months	9	665	Risk Ratio (M‐H, Random, 95% CI)	2.43 [1.23, 4.81]
10.1 Behaviour therapy	4	221	Risk Ratio (M‐H, Random, 95% CI)	1.84 [0.77, 4.41]
10.2 Cognitive‐behaviour therapy	5	444	Risk Ratio (M‐H, Random, 95% CI)	3.78 [1.26, 11.33]
11 Response/remission on continued treatment	3	229	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.93, 1.67]
11.1 Behaviour therapy	2	101	Risk Ratio (M‐H, Random, 95% CI)	1.64 [0.74, 3.61]
11.2 Cognitive‐behaviour therapy	1	128	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.81, 1.55]
12 Global/Avoidance/Panic on continued treatment	4	229	Std. Mean Difference (IV, Random, 95% CI)	‐0.76 [‐1.22, ‐0.31]
12.1 Behaviour therapy	3	101	Std. Mean Difference (IV, Random, 95% CI)	‐0.95 [‐1.37, ‐0.53]
12.2 Cognitive‐behaviour therapy	1	128	Std. Mean Difference (IV, Random, 95% CI)	‐0.36 [‐0.71, ‐0.01]
13 Dropouts for any reason on continued treatment	2	147	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.25, 2.43]
13.1 Behaviour therapy	1	19	Risk Ratio (M‐H, Random, 95% CI)	2.73 [0.12, 59.57]
13.2 Cognitive‐behaviour therapy	1	128	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.19, 2.18]
14 Response/remission 6‐24 months after treatment discontinuation	8	507	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.76, 1.15]
14.1 Behaviour therapy	5	284	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.78, 1.36]
14.2 Cognitive‐behaviour therapy	3	223	Risk Ratio (M‐H, Random, 95% CI)	0.84 [0.62, 1.13]
15 Global/Avoidance/Panic 6‐24 months after treatment discontinuation	5	245	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.15, 0.48]
15.1 Behaviour therapy	4	124	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.37, 0.53]
15.2 Cognitive‐behviour therapy	1	121	Std. Mean Difference (IV, Random, 95% CI)	0.29 [‐0.06, 0.65]