Comparison 4.

PD+/‐AGORAPHOBIA: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	23	1271	Risk Ratio (M‐H, Random, 95% CI)	1.17 [1.05, 1.31]
1.1 Behaviour therapy	12	562	Risk Ratio (M‐H, Random, 95% CI)	1.26 [1.05, 1.50]
1.2 Cognitive‐behaviour therapy	11	709	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.96, 1.33]
2 Remission at 2‐4 months	19	1107	Risk Ratio (M‐H, Random, 95% CI)	1.26 [1.10, 1.44]
2.1 Behaviour therapy	10	482	Risk Ratio (M‐H, Random, 95% CI)	1.37 [1.06, 1.77]
2.2 Cognitive‐behaviour therapy	9	625	Risk Ratio (M‐H, Random, 95% CI)	1.23 [1.02, 1.47]
3 Global severity at 2‐4 months	11	602	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐0.60, ‐0.26]
3.1 Behaviour therapy	6	239	Std. Mean Difference (IV, Random, 95% CI)	‐0.61 [‐0.87, ‐0.34]
3.2 Cognitive‐behaviour therapy	5	363	Std. Mean Difference (IV, Random, 95% CI)	‐0.31 [‐0.54, ‐0.08]
4 Frequency of panic attacks at 2‐4 months	13	497	Std. Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.21, 0.16]
4.1 Behaviour therapy	9	278	Std. Mean Difference (IV, Random, 95% CI)	0.06 [‐0.19, 0.31]
4.2 Cognitive‐behaviour therapy	4	219	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.41, 0.12]
5 Phobic avoidance at 2‐4 months	19	684	Std. Mean Difference (IV, Random, 95% CI)	‐0.31 [‐0.49, ‐0.12]
5.1 Behaviour therapy	12	396	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.70, ‐0.11]
5.2 Cognitive‐behaviour therapy	7	288	Std. Mean Difference (IV, Random, 95% CI)	‐0.20 [‐0.44, 0.04]
6 General anxiety at 2‐4 months	17	691	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.59, ‐0.23]
6.1 Behaviour therapy	9	302	Std. Mean Difference (IV, Random, 95% CI)	‐0.64 [‐0.90, ‐0.37]
6.2 Cognitive‐behaviour therapy	8	389	Std. Mean Difference (IV, Random, 95% CI)	‐0.23 [‐0.44, ‐0.03]
7 Depression at 2‐4 months	16	542	Std. Mean Difference (IV, Random, 95% CI)	‐0.39 [‐0.59, ‐0.20]
7.1 Behaviour therapy	11	350	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐0.69, ‐0.17]
7.2 Cognitive‐behaviour therapy	5	192	Std. Mean Difference (IV, Random, 95% CI)	‐0.34 [‐0.64, ‐0.05]
8 Social malfunctioning at 2‐4 months	11	404	Std. Mean Difference (IV, Random, 95% CI)	‐0.36 [‐0.61, ‐0.11]
8.1 Behaviour therapy	7	260	Std. Mean Difference (IV, Random, 95% CI)	‐0.55 [‐0.84, ‐0.26]
8.2 Cognitive‐behaviour therapy	4	144	Std. Mean Difference (IV, Random, 95% CI)	‐0.04 [‐0.39, 0.30]
9 Dropouts for any reason within 2‐4 months	20	1145	Risk Ratio (M‐H, Random, 95% CI)	1.18 [0.95, 1.47]
9.1 Behaviour therapy	10	480	Risk Ratio (M‐H, Random, 95% CI)	1.20 [0.90, 1.60]
9.2 Cognitive‐behaviour therapy	10	665	Risk Ratio (M‐H, Random, 95% CI)	1.16 [0.83, 1.62]
10 Dropouts due to side effects within 2‐4 months	13	846	Risk Ratio (M‐H, Random, 95% CI)	3.01 [1.61, 5.63]
10.1 Behaviour therapy	5	242	Risk Ratio (M‐H, Random, 95% CI)	1.99 [0.85, 4.62]
10.2 Cognitive‐behaviour therapy	8	604	Risk Ratio (M‐H, Random, 95% CI)	5.00 [1.96, 12.72]
11 Response/remission on continued treatment	4	306	Risk Ratio (M‐H, Random, 95% CI)	1.29 [1.03, 1.62]
11.1 Behaviour therapy	2	101	Risk Ratio (M‐H, Random, 95% CI)	1.64 [0.74, 3.61]
11.2 Cognitive‐behaviour therapy	2	205	Risk Ratio (M‐H, Random, 95% CI)	1.23 [0.93, 1.63]
12 Global/Avoidance/Panic on continued treatment	5	306	Std. Mean Difference (IV, Random, 95% CI)	‐0.65 [‐0.97, ‐0.33]
12.1 Behaviour therapy	3	101	Std. Mean Difference (IV, Random, 95% CI)	‐0.95 [‐1.37, ‐0.53]
12.2 Cognitive‐behaviour therapy	2	205	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.71, ‐0.12]
13 Dropouts for any reason on continued treatment	3	224	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.28, 2.15]
13.1 Behaviour therapy	1	19	Risk Ratio (M‐H, Random, 95% CI)	2.73 [0.12, 59.57]
13.2 Cognitive‐behaviour therapy	2	205	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.22, 1.95]
14 Response/remission 6‐24 months after treatment discontinuation	12	658	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.79, 1.16]
14.1 Behaviour therapy	7	319	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.77, 1.31]
14.2 Cognitive‐behaviour therapy	5	339	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.69, 1.21]
15 Global/Avoidance/Panic 6‐24 months after treatment discontinuation	7	335	Std. Mean Difference (IV, Random, 95% CI)	0.14 [‐0.09, 0.37]
15.1 Behaviour therapy	5	141	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.32, 0.43]
15.2 Cognitive‐behviour therapy	2	194	Std. Mean Difference (IV, Random, 95% CI)	0.21 [‐0.10, 0.52]