Comparison 6.

SUBGROUP2: TCA: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	12	760	Risk Ratio (M‐H, Random, 95% CI)	1.17 [1.01, 1.36]
1.1 Behaviour therapy	8	436	Risk Ratio (M‐H, Random, 95% CI)	1.22 [0.99, 1.50]
1.2 Cognitive‐behaviour therapy	4	324	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.89, 1.40]
2 Remission at 2‐4 months	10	653	Risk Ratio (M‐H, Random, 95% CI)	1.21 [1.00, 1.45]
2.1 Behaviour therapy	7	369	Risk Ratio (M‐H, Random, 95% CI)	1.38 [1.00, 1.90]
2.2 Cognitive‐behaviour therapy	3	284	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.90, 1.42]
3 Global severity at 2‐4 months	7	454	Std. Mean Difference (IV, Random, 95% CI)	‐0.48 [‐0.67, ‐0.28]
3.1 Behaviour therapy	4	183	Std. Mean Difference (IV, Random, 95% CI)	‐0.62 [‐0.92, ‐0.32]
3.2 Cognitive‐behaviour therapy	3	271	Std. Mean Difference (IV, Random, 95% CI)	‐0.39 [‐0.70, ‐0.07]
4 Frequency of panic attacks at 2‐4 months	8	265	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.09, 0.40]
4.1 Behaviour therapy	7	225	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.10, 0.43]
4.2 Cognitive‐behaviour therapy	1	40	Std. Mean Difference (IV, Random, 95% CI)	0.12 [‐0.50, 0.74]
5 Phobic avoidance at 2‐4 months	11	418	Std. Mean Difference (IV, Random, 95% CI)	‐0.21 [‐0.44, 0.02]
5.1 Behaviour therapy	9	312	Std. Mean Difference (IV, Random, 95% CI)	‐0.22 [‐0.51, 0.07]
5.2 Cognitive‐behaviour therapy	2	106	Std. Mean Difference (IV, Random, 95% CI)	‐0.19 [‐0.59, 0.20]
6 General anxiety at 2‐4 months	7	284	Std. Mean Difference (IV, Random, 95% CI)	‐0.49 [‐0.73, ‐0.25]
6.1 Behaviour therapy	6	218	Std. Mean Difference (IV, Random, 95% CI)	‐0.50 [‐0.80, ‐0.21]
6.2 Cognitive‐behaviour therapy	1	66	Std. Mean Difference (IV, Random, 95% CI)	‐0.42 [‐0.93, 0.08]
7 Depression at 2‐4 months	10	372	Std. Mean Difference (IV, Random, 95% CI)	‐0.29 [‐0.50, ‐0.07]
7.1 Behaviour therapy	8	266	Std. Mean Difference (IV, Random, 95% CI)	‐0.28 [‐0.53, ‐0.03]
7.2 Cognitive‐behaviour therapy	2	106	Std. Mean Difference (IV, Random, 95% CI)	‐0.27 [‐0.90, 0.37]
8 Social malfunctioning at 2‐4 months	6	232	Std. Mean Difference (IV, Random, 95% CI)	‐0.48 [‐0.75, ‐0.22]
8.1 Behaviour therapy	6	232	Std. Mean Difference (IV, Random, 95% CI)	‐0.48 [‐0.75, ‐0.22]
8.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
9 Dropouts for any reason within 2‐4 months	11	692	Risk Ratio (M‐H, Random, 95% CI)	1.16 [0.90, 1.49]
9.1 Behaviour therapy	7	368	Risk Ratio (M‐H, Random, 95% CI)	1.16 [0.85, 1.59]
9.2 Cognitive‐behaviour therapy	4	324	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.73, 1.89]
10 Dropouts due to side effects within 2‐4 months	7	497	Risk Ratio (M‐H, Random, 95% CI)	2.50 [1.15, 5.45]
10.1 Behaviour therapy	3	173	Risk Ratio (M‐H, Random, 95% CI)	1.68 [0.67, 4.18]
10.2 Cognitive‐behaviour therapy	4	324	Risk Ratio (M‐H, Random, 95% CI)	7.31 [1.64, 32.67]
11 Response/remission on continued treatment	5	390	Risk Ratio (M‐H, Random, 95% CI)	1.23 [1.00, 1.51]
11.1 Behaviour therapy	3	185	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.82, 1.90]
11.2 Cognitive‐behaviour therapy	2	205	Risk Ratio (M‐H, Random, 95% CI)	1.23 [0.93, 1.63]
12 Global/Avoidance/Panic on continued treatment	5	306	Std. Mean Difference (IV, Random, 95% CI)	‐0.65 [‐0.97, ‐0.33]
12.1 Behaviour therapy	3	101	Std. Mean Difference (IV, Random, 95% CI)	‐0.95 [‐1.37, ‐0.53]
12.2 Cognitive‐behaviour therapy	2	205	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.71, ‐0.12]
13 Dropouts for any reason on continued treatment	3	224	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.28, 2.15]
13.1 Behaviour therapy	1	19	Risk Ratio (M‐H, Random, 95% CI)	2.73 [0.12, 59.57]
13.2 Cognitive‐behaviour therapy	2	205	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.22, 1.95]
18 Response 6‐24 months after treatment discontinuation	7	444	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.70, 1.18]
18.1 Behaviour therapy	5	250	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.73, 1.36]
18.2 Cognitive‐behaviour therapy	2	194	Risk Ratio (M‐H, Random, 95% CI)	0.74 [0.46, 1.19]
19 Global/Avoidance/Panic 6‐24 months after treatment discontinuation	5	281	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.14, 0.45]
19.1 Behaviour therapy	3	87	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.59, 0.75]
19.2 Cognitive‐behviour therapy	2	194	Std. Mean Difference (IV, Random, 95% CI)	0.21 [‐0.10, 0.52]