Comparison 6.
SUBGROUP2: TCA: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 12 | 760 | Risk Ratio (M‐H, Random, 95% CI) | 1.17 [1.01, 1.36] |
| 1.1 Behaviour therapy | 8 | 436 | Risk Ratio (M‐H, Random, 95% CI) | 1.22 [0.99, 1.50] |
| 1.2 Cognitive‐behaviour therapy | 4 | 324 | Risk Ratio (M‐H, Random, 95% CI) | 1.12 [0.89, 1.40] |
| 2 Remission at 2‐4 months | 10 | 653 | Risk Ratio (M‐H, Random, 95% CI) | 1.21 [1.00, 1.45] |
| 2.1 Behaviour therapy | 7 | 369 | Risk Ratio (M‐H, Random, 95% CI) | 1.38 [1.00, 1.90] |
| 2.2 Cognitive‐behaviour therapy | 3 | 284 | Risk Ratio (M‐H, Random, 95% CI) | 1.13 [0.90, 1.42] |
| 3 Global severity at 2‐4 months | 7 | 454 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐0.67, ‐0.28] |
| 3.1 Behaviour therapy | 4 | 183 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.62 [‐0.92, ‐0.32] |
| 3.2 Cognitive‐behaviour therapy | 3 | 271 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.39 [‐0.70, ‐0.07] |
| 4 Frequency of panic attacks at 2‐4 months | 8 | 265 | Std. Mean Difference (IV, Random, 95% CI) | 0.16 [‐0.09, 0.40] |
| 4.1 Behaviour therapy | 7 | 225 | Std. Mean Difference (IV, Random, 95% CI) | 0.16 [‐0.10, 0.43] |
| 4.2 Cognitive‐behaviour therapy | 1 | 40 | Std. Mean Difference (IV, Random, 95% CI) | 0.12 [‐0.50, 0.74] |
| 5 Phobic avoidance at 2‐4 months | 11 | 418 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.21 [‐0.44, 0.02] |
| 5.1 Behaviour therapy | 9 | 312 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.22 [‐0.51, 0.07] |
| 5.2 Cognitive‐behaviour therapy | 2 | 106 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.19 [‐0.59, 0.20] |
| 6 General anxiety at 2‐4 months | 7 | 284 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.49 [‐0.73, ‐0.25] |
| 6.1 Behaviour therapy | 6 | 218 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.50 [‐0.80, ‐0.21] |
| 6.2 Cognitive‐behaviour therapy | 1 | 66 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.42 [‐0.93, 0.08] |
| 7 Depression at 2‐4 months | 10 | 372 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.29 [‐0.50, ‐0.07] |
| 7.1 Behaviour therapy | 8 | 266 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.28 [‐0.53, ‐0.03] |
| 7.2 Cognitive‐behaviour therapy | 2 | 106 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.27 [‐0.90, 0.37] |
| 8 Social malfunctioning at 2‐4 months | 6 | 232 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐0.75, ‐0.22] |
| 8.1 Behaviour therapy | 6 | 232 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐0.75, ‐0.22] |
| 8.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Dropouts for any reason within 2‐4 months | 11 | 692 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [0.90, 1.49] |
| 9.1 Behaviour therapy | 7 | 368 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [0.85, 1.59] |
| 9.2 Cognitive‐behaviour therapy | 4 | 324 | Risk Ratio (M‐H, Random, 95% CI) | 1.17 [0.73, 1.89] |
| 10 Dropouts due to side effects within 2‐4 months | 7 | 497 | Risk Ratio (M‐H, Random, 95% CI) | 2.50 [1.15, 5.45] |
| 10.1 Behaviour therapy | 3 | 173 | Risk Ratio (M‐H, Random, 95% CI) | 1.68 [0.67, 4.18] |
| 10.2 Cognitive‐behaviour therapy | 4 | 324 | Risk Ratio (M‐H, Random, 95% CI) | 7.31 [1.64, 32.67] |
| 11 Response/remission on continued treatment | 5 | 390 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [1.00, 1.51] |
| 11.1 Behaviour therapy | 3 | 185 | Risk Ratio (M‐H, Random, 95% CI) | 1.25 [0.82, 1.90] |
| 11.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [0.93, 1.63] |
| 12 Global/Avoidance/Panic on continued treatment | 5 | 306 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.65 [‐0.97, ‐0.33] |
| 12.1 Behaviour therapy | 3 | 101 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.95 [‐1.37, ‐0.53] |
| 12.2 Cognitive‐behaviour therapy | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.71, ‐0.12] |
| 13 Dropouts for any reason on continued treatment | 3 | 224 | Risk Ratio (M‐H, Random, 95% CI) | 0.77 [0.28, 2.15] |
| 13.1 Behaviour therapy | 1 | 19 | Risk Ratio (M‐H, Random, 95% CI) | 2.73 [0.12, 59.57] |
| 13.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.66 [0.22, 1.95] |
| 18 Response 6‐24 months after treatment discontinuation | 7 | 444 | Risk Ratio (M‐H, Random, 95% CI) | 0.91 [0.70, 1.18] |
| 18.1 Behaviour therapy | 5 | 250 | Risk Ratio (M‐H, Random, 95% CI) | 1.00 [0.73, 1.36] |
| 18.2 Cognitive‐behaviour therapy | 2 | 194 | Risk Ratio (M‐H, Random, 95% CI) | 0.74 [0.46, 1.19] |
| 19 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 5 | 281 | Std. Mean Difference (IV, Random, 95% CI) | 0.16 [‐0.14, 0.45] |
| 19.1 Behaviour therapy | 3 | 87 | Std. Mean Difference (IV, Random, 95% CI) | 0.08 [‐0.59, 0.75] |
| 19.2 Cognitive‐behviour therapy | 2 | 194 | Std. Mean Difference (IV, Random, 95% CI) | 0.21 [‐0.10, 0.52] |