Comparison 7.
SUBGROUP2: SSRI: Psychotherapy+Antidepressant vs Antidepressant alone
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 3 | 218 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [0.75, 2.03] |
| 1.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 1.2 Cognitive‐behaviour therapy | 2 | 118 | Risk Ratio (M‐H, Random, 95% CI) | 1.68 [0.69, 4.05] |
| 1.3 Psychodynamic psychotherapy and others | 1 | 100 | Risk Ratio (M‐H, Random, 95% CI) | 0.85 [0.63, 1.15] |
| 2 Remission at 2‐4 months | 2 | 174 | Risk Ratio (M‐H, Random, 95% CI) | 0.80 [0.38, 1.70] |
| 2.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2.2 Cognitive‐behaviour therapy | 1 | 74 | Risk Ratio (M‐H, Random, 95% CI) | 1.14 [0.78, 1.66] |
| 2.3 Psychodynamic psychotherapy and others | 1 | 100 | Risk Ratio (M‐H, Random, 95% CI) | 0.54 [0.32, 0.90] |
| 3 Global severity at 2‐4 months | 1 | 58 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐1.01, 0.04] |
| 3.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3.2 Cognitive‐behaviour therapy | 1 | 58 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐1.01, 0.04] |
| 3.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 2 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.47 [‐1.39, 0.45] |
| 4.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4.2 Cognitive‐behaviour therapy | 2 | 86 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.76 [‐2.34, 0.83] |
| 4.3 Psychodynamic psychotherapy and others | 1 | 52 | Std. Mean Difference (IV, Random, 95% CI) | 0.03 [‐0.53, 0.59] |
| 5 Phobic avoidance at 2‐4 months | 1 | 104 | Std. Mean Difference (IV, Random, 95% CI) | 0.57 [0.16, 0.97] |
| 5.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5.2 Cognitive‐behaviour therapy | 1 | 52 | Std. Mean Difference (IV, Random, 95% CI) | 0.57 [‐0.00, 1.14] |
| 5.3 Psychodynamic psychotherapy and others | 1 | 52 | Std. Mean Difference (IV, Random, 95% CI) | 0.57 [‐0.00, 1.14] |
| 6 General anxiety at 2‐4 months | 3 | 196 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.22 [‐0.93, 0.49] |
| 6.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6.2 Cognitive‐behaviour therapy | 3 | 144 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.43 [‐1.32, 0.45] |
| 6.3 Psychodynamic psychotherapy and others | 1 | 52 | Std. Mean Difference (IV, Random, 95% CI) | 0.39 [‐0.18, 0.95] |
| 7 Depression at 2‐4 months | 1 | 34 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.89 [‐1.60, ‐0.18] |
| 7.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7.2 Cognitive‐behaviour therapy | 1 | 34 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.89 [‐1.60, ‐0.18] |
| 7.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 1 | 58 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.82, 0.22] |
| 8.1 Behavour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8.2 Cognitive‐behaviour therapy | 1 | 58 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.82, 0.22] |
| 8.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Dropouts for any reason within 2‐4 months | 3 | 218 | Risk Ratio (M‐H, Random, 95% CI) | 1.04 [0.68, 1.60] |
| 9.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9.2 Cognitive‐behaviour therapy | 2 | 118 | Risk Ratio (M‐H, Random, 95% CI) | 0.90 [0.51, 1.61] |
| 9.3 Psychodynamic psychotherapy and others | 1 | 100 | Risk Ratio (M‐H, Random, 95% CI) | 1.25 [0.65, 2.39] |
| 10 Dropouts due to side effects within 2‐4 months | 1 | 74 | Risk Ratio (M‐H, Random, 95% CI) | 1.58 [0.41, 6.13] |
| 10.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10.2 Cognitive‐behaviour therapy | 1 | 74 | Risk Ratio (M‐H, Random, 95% CI) | 1.58 [0.41, 6.13] |
| 10.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11 Response/remission on continued treatment | 1 | 73 | Risk Ratio (M‐H, Random, 95% CI) | 0.67 [0.44, 1.02] |
| 11.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.3 Psychdynamic psychotherapy and others | 1 | 73 | Risk Ratio (M‐H, Random, 95% CI) | 0.67 [0.44, 1.02] |
| 12 Global/Avoidance/Panic on continued treatment | 1 | 50 | Std. Mean Difference (IV, Random, 95% CI) | 0.42 [‐0.15, 0.99] |
| 12.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.3 Psychodynamic psychotherapy and others | 1 | 50 | Std. Mean Difference (IV, Random, 95% CI) | 0.42 [‐0.15, 0.99] |
| 13 Dropouts for any reason on continued treatment | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14 Response/remission immediately after treatment discontinuation | 1 | 50 | Risk Ratio (M‐H, Random, 95% CI) | 0.85 [0.65, 1.11] |
| 14.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.3 Psychodynamic psychotherapy and others | 1 | 50 | Risk Ratio (M‐H, Random, 95% CI) | 0.85 [0.65, 1.11] |
| 15 Global/Avoidance/Panic immediately after treatment discontinuation | 1 | 50 | Std. Mean Difference (IV, Random, 95% CI) | 0.42 [‐0.15, 0.99] |
| 15.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.3 Psychodynamic psychotherapy and others | 1 | 50 | Std. Mean Difference (IV, Random, 95% CI) | 0.42 [‐0.15, 0.99] |
| 16 Response/remission 6‐24 months after treatment discontinuation | 1 | 74 | Risk Ratio (M‐H, Random, 95% CI) | 1.52 [0.80, 2.89] |
| 16.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 16.2 Cognitive‐behaviour therapy | 1 | 74 | Risk Ratio (M‐H, Random, 95% CI) | 1.52 [0.80, 2.89] |
| 16.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |