Comparison 8.

SUBGROUP2: SSRI: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	8	426	Risk Ratio (M‐H, Random, 95% CI)	1.24 [0.94, 1.65]
1.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	2.93 [1.07, 7.99]
1.2 Cognitive‐behaviour therapy	6	357	Risk Ratio (M‐H, Random, 95% CI)	1.16 [0.89, 1.53]
2 Remission at 2‐4 months	7	382	Risk Ratio (M‐H, Random, 95% CI)	1.31 [1.04, 1.65]
2.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	1.15 [0.79, 1.68]
2.2 Cognitive‐behaviour therapy	5	313	Risk Ratio (M‐H, Random, 95% CI)	1.39 [1.01, 1.92]
3 Global severity at 2‐4 months	4	148	Std. Mean Difference (IV, Random, 95% CI)	‐0.29 [‐0.64, 0.06]
3.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.58 [‐1.14, ‐0.01]
3.2 Cognitive‐behaviour therapy	2	92	Std. Mean Difference (IV, Random, 95% CI)	‐0.12 [‐0.56, 0.32]
4 Frequency of panic attacks at 2‐4 months	5	232	Std. Mean Difference (IV, Random, 95% CI)	‐0.24 [‐0.50, 0.02]
4.1 Behaviour therapy	2	53	Std. Mean Difference (IV, Random, 95% CI)	‐0.37 [‐0.95, 0.20]
4.2 Cognitive‐behaviour therapy	3	179	Std. Mean Difference (IV, Random, 95% CI)	‐0.21 [‐0.50, 0.09]
5 Phobic avoidance at 2‐4 months	6	210	Std. Mean Difference (IV, Random, 95% CI)	‐0.39 [‐0.71, ‐0.06]
5.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.99 [‐1.57, ‐0.40]
5.2 Cognitive‐behaviour therapy	4	154	Std. Mean Difference (IV, Random, 95% CI)	‐0.18 [‐0.51, 0.15]
6 General anxiety at 2‐4 months	8	351	Std. Mean Difference (IV, Random, 95% CI)	‐0.30 [‐0.54, ‐0.07]
6.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.88 [‐1.46, ‐0.30]
6.2 Cognitive‐behaviour therapy	6	295	Std. Mean Difference (IV, Random, 95% CI)	‐0.21 [‐0.45, 0.02]
7 Depression at 2‐4 months	4	114	Std. Mean Difference (IV, Random, 95% CI)	‐0.62 [‐1.01, ‐0.24]
7.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.76 [‐1.34, ‐0.19]
7.2 Cognitive‐behaviour therapy	2	58	Std. Mean Difference (IV, Random, 95% CI)	‐0.51 [‐1.03, 0.02]
8 Social malfunctioning at 2‐4 months	3	116	Std. Mean Difference (IV, Random, 95% CI)	‐0.09 [‐0.47, 0.30]
8.1 Behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
8.2 Cognitive‐behaviour therapy	3	116	Std. Mean Difference (IV, Random, 95% CI)	‐0.09 [‐0.47, 0.30]
9 Dropouts for any reason within 2‐4 months	7	382	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.70, 1.80]
9.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.44, 3.22]
9.2 Cognitive‐behaviour therapy	5	313	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.64, 1.93]
10 Dropouts due to side effects within 2‐4 months	6	349	Risk Ratio (M‐H, Random, 95% CI)	4.22 [1.47, 12.08]
10.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	5.41 [0.59, 49.42]
10.2 Cognitive‐behaviour therapy	4	280	Risk Ratio (M‐H, Random, 95% CI)	3.93 [1.19, 12.97]
11 Response/remission on continued treatment	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
11.1 Behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
11.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
12 Global/Avoidance/Panic on continued treatment	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
12.1 Behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
12.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
13 Dropouts for any reason on continued treatment	1	38	Risk Ratio (M‐H, Random, 95% CI)	3.00 [0.13, 69.31]
13.1 Behaviour therapy	1	38	Risk Ratio (M‐H, Random, 95% CI)	3.00 [0.13, 69.31]
13.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
18 Response 6‐24 months after treatment discontinuation	4	186	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.73, 1.44]
18.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.62, 1.69]
18.2 Cognitive‐behaviour therapy	2	117	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.65, 1.63]
19 Global/Avoidance/Panic 6‐24 months after treatment discontinuation	2	54	Std. Mean Difference (IV, Random, 95% CI)	0.01 [‐0.56, 0.58]
19.1 Behaviour therapy	2	54	Std. Mean Difference (IV, Random, 95% CI)	0.01 [‐0.56, 0.58]
19.2 Cognitive‐behviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]