Comparison 9.
SUBGROUP3: 100%agoraphobia: Psychotherapy+Antidepressant vs Antidepressant alone
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 5 | 223 | Risk Ratio (M‐H, Random, 95% CI) | 1.35 [0.88, 2.08] |
| 1.1 Behaviour therapy | 4 | 193 | Risk Ratio (M‐H, Random, 95% CI) | 1.06 [0.80, 1.40] |
| 1.2 Cognitive‐behaviour therapy | 1 | 30 | Risk Ratio (M‐H, Random, 95% CI) | 2.51 [1.16, 5.47] |
| 1.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Remission at 2‐4 months | 3 | 144 | Risk Ratio (M‐H, Random, 95% CI) | 1.36 [0.63, 2.96] |
| 2.1 Behaviour therapy | 2 | 114 | Risk Ratio (M‐H, Random, 95% CI) | 0.97 [0.62, 1.51] |
| 2.2 Cognitive‐behaviour therapy | 1 | 30 | Risk Ratio (M‐H, Random, 95% CI) | 5.14 [1.33, 19.92] |
| 2.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Global severity at 2‐4 months | 2 | 90 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.51 [‐1.45, 0.44] |
| 3.1 Behaviour therapy | 2 | 90 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.51 [‐1.45, 0.44] |
| 3.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 4 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.15 [‐0.49, 0.19] |
| 4.1 Behaviour therapy | 4 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.15 [‐0.49, 0.19] |
| 4.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Phobic avoidance at 2‐4 months | 6 | 226 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.51 [‐0.89, ‐0.13] |
| 5.1 Behaviour therapy | 4 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.53 [‐1.01, ‐0.06] |
| 5.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.53 [‐1.45, 0.39] |
| 5.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 3 | 120 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.36 [‐0.77, 0.05] |
| 6.1 Behaviour therapy | 2 | 90 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.19 [‐0.60, 0.23] |
| 6.2 Cognitive‐behaviour therapy | 1 | 30 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.79 [‐1.54, ‐0.04] |
| 6.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 5 | 168 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.45 [‐0.77, ‐0.13] |
| 7.1 Behaviour therapy | 4 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.35 [‐0.69, ‐0.01] |
| 7.2 Cognitive‐behaviour therapy | 1 | 30 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.93 [‐1.69, ‐0.17] |
| 7.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 4 | 148 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.53 [‐1.02, ‐0.05] |
| 8.1 Behavour therapy | 3 | 118 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.68, 0.08] |
| 8.2 Cognitive‐behaviour therapy | 1 | 30 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.08 [‐1.85, ‐0.30] |
| 8.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Dropouts for any reason within 2‐4 months | 5 | 223 | Risk Ratio (M‐H, Random, 95% CI) | 1.08 [0.72, 1.63] |
| 9.1 Behaviour therapy | 4 | 193 | Risk Ratio (M‐H, Random, 95% CI) | 1.21 [0.78, 1.88] |
| 9.2 Cognitive‐behaviour therapy | 1 | 30 | Risk Ratio (M‐H, Random, 95% CI) | 0.49 [0.16, 1.54] |
| 9.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Dropouts due to side effects within 2‐4 months | 2 | 43 | Risk Ratio (M‐H, Random, 95% CI) | 0.97 [0.27, 3.58] |
| 10.1 Behaviour therapy | 2 | 43 | Risk Ratio (M‐H, Random, 95% CI) | 0.97 [0.27, 3.58] |
| 10.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11 Response/remission on continued treatment | 2 | 121 | Risk Ratio (M‐H, Random, 95% CI) | 1.94 [1.10, 3.41] |
| 11.1 Behaviour therapy | 2 | 121 | Risk Ratio (M‐H, Random, 95% CI) | 1.94 [1.10, 3.41] |
| 11.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.3 Psychdynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12 Global/Avoidance/Panic on continued treatment | 2 | 48 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.91 [‐1.51, ‐0.30] |
| 12.1 Behaviour therapy | 2 | 48 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.91 [‐1.51, ‐0.30] |
| 12.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13 Dropouts for any reason on continued treatment | 1 | 20 | Risk Ratio (M‐H, Random, 95% CI) | 1.0 [0.07, 13.87] |
| 13.1 Behaviour therapy | 1 | 20 | Risk Ratio (M‐H, Random, 95% CI) | 1.0 [0.07, 13.87] |
| 13.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14 Response/remission immediately after treatment discontinuation | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15 Global/Avoidance/Panic immediately after treatment discontinuation | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 16 Response/remission 6‐24 months after treatment discontinuation | 2 | 126 | Risk Ratio (M‐H, Random, 95% CI) | 1.48 [1.02, 2.17] |
| 16.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 1.49 [0.95, 2.35] |
| 16.2 Cognitive‐behaviour therapy | 1 | 30 | Risk Ratio (M‐H, Random, 95% CI) | 1.47 [0.75, 2.90] |
| 16.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |