Comparison 10.

SUBGROUP3: 100%agoraphobia: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	12	576	Risk Ratio (M‐H, Random, 95% CI)	1.18 [1.00, 1.40]
1.1 Behaviour therapy	11	548	Risk Ratio (M‐H, Random, 95% CI)	1.28 [1.05, 1.56]
1.2 Cognitive‐behaviour therapy	1	28	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.65, 1.30]
2 Remission at 2‐4 months	11	510	Risk Ratio (M‐H, Random, 95% CI)	1.28 [1.02, 1.60]
2.1 Behaviour therapy	10	482	Risk Ratio (M‐H, Random, 95% CI)	1.31 [1.03, 1.66]
2.2 Cognitive‐behaviour therapy	1	28	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.62, 2.05]
3 Global severity at 2‐4 months	6	239	Std. Mean Difference (IV, Random, 95% CI)	‐0.61 [‐0.87, ‐0.34]
3.1 Behaviour therapy	6	239	Std. Mean Difference (IV, Random, 95% CI)	‐0.61 [‐0.87, ‐0.34]
3.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4 Frequency of panic attacks at 2‐4 months	9	278	Std. Mean Difference (IV, Random, 95% CI)	0.06 [‐0.19, 0.31]
4.1 Behaviour therapy	9	278	Std. Mean Difference (IV, Random, 95% CI)	0.06 [‐0.19, 0.31]
4.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
5 Phobic avoidance at 2‐4 months	13	424	Std. Mean Difference (IV, Random, 95% CI)	‐0.39 [‐0.67, ‐0.12]
5.1 Behaviour therapy	12	396	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.70, ‐0.11]
5.2 Cognitive‐behaviour therapy	1	28	Std. Mean Difference (IV, Random, 95% CI)	‐0.28 [‐1.03, 0.46]
6 General anxiety at 2‐4 months	10	330	Std. Mean Difference (IV, Random, 95% CI)	‐0.58 [‐0.85, ‐0.32]
6.1 Behaviour therapy	9	302	Std. Mean Difference (IV, Random, 95% CI)	‐0.64 [‐0.90, ‐0.37]
6.2 Cognitive‐behaviour therapy	1	28	Std. Mean Difference (IV, Random, 95% CI)	‐0.04 [‐0.78, 0.70]
7 Depression at 2‐4 months	12	378	Std. Mean Difference (IV, Random, 95% CI)	‐0.40 [‐0.65, ‐0.16]
7.1 Behaviour therapy	11	350	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐0.69, ‐0.17]
7.2 Cognitive‐behaviour therapy	1	28	Std. Mean Difference (IV, Random, 95% CI)	‐0.16 [‐0.90, 0.58]
8 Social malfunctioning at 2‐4 months	8	288	Std. Mean Difference (IV, Random, 95% CI)	‐0.47 [‐0.77, ‐0.17]
8.1 Behaviour therapy	7	260	Std. Mean Difference (IV, Random, 95% CI)	‐0.55 [‐0.84, ‐0.26]
8.2 Cognitive‐behaviour therapy	1	28	Std. Mean Difference (IV, Random, 95% CI)	0.11 [‐0.63, 0.85]
9 Dropouts for any reason within 2‐4 months	11	508	Risk Ratio (M‐H, Random, 95% CI)	1.22 [0.91, 1.62]
9.1 Behaviour therapy	10	480	Risk Ratio (M‐H, Random, 95% CI)	1.20 [0.90, 1.60]
9.2 Cognitive‐behaviour therapy	1	28	Risk Ratio (M‐H, Random, 95% CI)	3.00 [0.35, 25.46]
10 Dropouts due to side effects within 2‐4 months	5	242	Risk Ratio (M‐H, Random, 95% CI)	1.99 [0.85, 4.62]
10.1 Behaviour therapy	5	242	Risk Ratio (M‐H, Random, 95% CI)	1.99 [0.85, 4.62]
10.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
11 Response/remission on continued treatment	3	185	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.82, 1.90]
11.1 Behaviour therapy	3	185	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.82, 1.90]
11.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
12 Global/Avoidance/Panic on continued treatment	3	101	Std. Mean Difference (IV, Random, 95% CI)	‐0.95 [‐1.37, ‐0.53]
12.1 Behaviour therapy	3	101	Std. Mean Difference (IV, Random, 95% CI)	‐0.95 [‐1.37, ‐0.53]
12.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
13 Dropouts for any reason on continued treatment	2	57	Risk Ratio (M‐H, Random, 95% CI)	2.86 [0.32, 25.80]
13.1 Behaviour therapy	2	57	Risk Ratio (M‐H, Random, 95% CI)	2.86 [0.32, 25.80]
13.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
18 Response 6‐24 months after treatment discontinuation	8	347	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.79, 1.27]
18.1 Behaviour therapy	7	319	Risk Ratio (M‐H, Random, 95% CI)	1.00 [0.77, 1.31]
18.2 Cognitive‐behaviour therapy	1	28	Risk Ratio (M‐H, Random, 95% CI)	1.0 [0.58, 1.74]
19 Global/Avoidance/Panic 6‐24 months after treatment discontinuation	5	141	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.32, 0.43]
19.1 Behaviour therapy	5	141	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.32, 0.43]
19.2 Cognitive‐behviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]