Comparison 11.
SUBGROUP3: 0%agoraphobia: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.08 [0.84, 1.38] |
| 1.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 1.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.08 [0.84, 1.38] |
| 2 Remission at 2‐4 months | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.09 [0.85, 1.40] |
| 2.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.09 [0.85, 1.40] |
| 3 Global severity at 2‐4 months | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.25 [‐0.55, 0.04] |
| 3.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3.2 Cognitive‐behaviour therapy | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.25 [‐0.55, 0.04] |
| 4 Frequency of panic attacks at 2‐4 months | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Phobic avoidance at 2‐4 months | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social malfunctioning at 2‐4 months | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Dropouts for any reason within 2‐4 months | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.99 [0.62, 1.60] |
| 9.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.99 [0.62, 1.60] |
| 10 Dropouts due to side effects within 2‐4 months | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 6.33 [0.67, 59.70] |
| 10.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 6.33 [0.67, 59.70] |
| 11 Response/remission on continued treatment | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [0.93, 1.63] |
| 11.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [0.93, 1.63] |
| 12 Global/Avoidance/Panic on continued treatment | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.71, ‐0.12] |
| 12.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Cognitive‐behaviour therapy | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.71, ‐0.12] |
| 13 Dropouts for any reason on continued treatment | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.66 [0.22, 1.95] |
| 13.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.66 [0.22, 1.95] |
| 18 Response 6‐24 months after treatment discontinuation | 2 | 194 | Risk Ratio (M‐H, Random, 95% CI) | 0.74 [0.46, 1.19] |
| 18.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 18.2 Cognitive‐behaviour therapy | 2 | 194 | Risk Ratio (M‐H, Random, 95% CI) | 0.74 [0.46, 1.19] |
| 19 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 2 | 194 | Std. Mean Difference (IV, Random, 95% CI) | 0.21 [‐0.10, 0.52] |
| 19.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 19.2 Cognitive‐behviour therapy | 2 | 194 | Std. Mean Difference (IV, Random, 95% CI) | 0.21 [‐0.10, 0.52] |