Comparison 12.
SUBGROUP4: without comorbidity: Psychotherapy+Antidepressant vs Antidepressant alone
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 5 | 265 | Risk Ratio (M‐H, Random, 95% CI) | 1.25 [0.86, 1.82] |
| 1.1 Behaviour therapy | 2 | 121 | Risk Ratio (M‐H, Random, 95% CI) | 1.57 [0.35, 7.03] |
| 1.2 Cognitive‐behaviour therapy | 3 | 144 | Risk Ratio (M‐H, Random, 95% CI) | 1.37 [0.79, 2.39] |
| 1.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Remission at 2‐4 months | 3 | 200 | Risk Ratio (M‐H, Random, 95% CI) | 1.34 [0.72, 2.51] |
| 2.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 0.94 [0.52, 1.72] |
| 2.2 Cognitive‐behaviour therapy | 2 | 104 | Risk Ratio (M‐H, Random, 95% CI) | 2.13 [0.45, 10.10] |
| 2.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Global severity at 2‐4 months | 2 | 133 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.29 [‐0.63, 0.05] |
| 3.1 Behaviour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.14 [‐0.60, 0.31] |
| 3.2 Cognitive‐behaviour therapy | 1 | 58 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐1.01, 0.04] |
| 3.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 3 | 134 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.17 [‐0.51, 0.17] |
| 4.1 Behaviour therapy | 2 | 95 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.28 [‐0.69, 0.13] |
| 4.2 Cognitive‐behaviour therapy | 1 | 39 | Std. Mean Difference (IV, Random, 95% CI) | 0.08 [‐0.55, 0.71] |
| 4.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Phobic avoidance at 2‐4 months | 4 | 164 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.39 [1.00, 0.21] |
| 5.1 Behaviour therapy | 2 | 95 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.45 [‐1.29, 0.39] |
| 5.2 Cognitive‐behaviour therapy | 2 | 69 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.36 [‐1.67, 0.96] |
| 5.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 3 | 163 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.38 [‐0.74, ‐0.03] |
| 6.1 Behaviour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.13 [‐0.58, 0.33] |
| 6.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.58 [‐1.01, ‐0.15] |
| 6.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 4 | 164 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.37 [‐0.69, ‐0.06] |
| 7.1 Behaviour therapy | 2 | 95 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.27 [‐0.67, 0.14] |
| 7.2 Cognitive‐behaviour therapy | 2 | 69 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.56 [‐1.22, 0.11] |
| 7.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 3 | 163 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.43 [‐0.89, 0.04] |
| 8.1 Behavour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.17 [‐0.62, 0.29] |
| 8.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.63 [‐1.39, 0.12] |
| 8.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Dropouts for any reason within 2‐4 months | 5 | 265 | Risk Ratio (M‐H, Random, 95% CI) | 0.86 [0.57, 1.31] |
| 9.1 Behaviour therapy | 2 | 121 | Risk Ratio (M‐H, Random, 95% CI) | 1.00 [0.50, 1.99] |
| 9.2 Cognitive‐behaviour therapy | 3 | 144 | Risk Ratio (M‐H, Random, 95% CI) | 0.79 [0.46, 1.34] |
| 9.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Dropouts due to side effects within 2‐4 months | 3 | 139 | Risk Ratio (M‐H, Random, 95% CI) | 1.43 [0.63, 3.27] |
| 10.1 Behaviour therapy | 1 | 25 | Risk Ratio (M‐H, Random, 95% CI) | 1.38 [0.28, 6.91] |
| 10.2 Cognitive‐behaviour therapy | 2 | 114 | Risk Ratio (M‐H, Random, 95% CI) | 1.45 [0.55, 3.80] |
| 10.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11 Response/remission on continued treatment | 2 | 121 | Risk Ratio (M‐H, Random, 95% CI) | 1.94 [1.10, 3.41] |
| 11.1 Behaviour therapy | 2 | 121 | Risk Ratio (M‐H, Random, 95% CI) | 1.94 [1.10, 3.41] |
| 11.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.3 Psychdynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12 Global/Avoidance/Panic on continued treatment | 1 | 20 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.23 [‐2.20, ‐0.26] |
| 12.1 Behaviour therapy | 1 | 20 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.23 [‐2.20, ‐0.26] |
| 12.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13 Dropouts for any reason on continued treatment | 1 | 20 | Risk Ratio (M‐H, Random, 95% CI) | 1.0 [0.07, 13.87] |
| 13.1 Behaviour therapy | 1 | 20 | Risk Ratio (M‐H, Random, 95% CI) | 1.0 [0.07, 13.87] |
| 13.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14 Response/remission immediately after treatment discontinuation | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15 Global/Avoidance/Panic immediately after treatment discontinuation | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 15.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 16 Response/remission 6‐24 months after treatment discontinuation | 3 | 200 | Risk Ratio (M‐H, Random, 95% CI) | 1.49 [1.08, 2.07] |
| 16.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 1.49 [0.95, 2.35] |
| 16.2 Cognitive‐behaviour therapy | 2 | 104 | Risk Ratio (M‐H, Random, 95% CI) | 1.49 [0.94, 2.38] |
| 16.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |