Comparison 13.

SUBGROUP4: without comorbidity: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	12	675	Risk Ratio (M‐H, Random, 95% CI)	1.15 [1.01, 1.32]
1.1 Behaviour therapy	6	337	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.97, 1.51]
1.2 Cognitive‐behaviour therapy	6	338	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.89, 1.40]
2 Remission at 2‐4 months	10	610	Risk Ratio (M‐H, Random, 95% CI)	1.37 [1.11, 1.70]
2.1 Behaviour therapy	5	312	Risk Ratio (M‐H, Random, 95% CI)	1.45 [1.04, 2.03]
2.2 Cognitive‐behaviour therapy	5	298	Risk Ratio (M‐H, Random, 95% CI)	1.32 [0.95, 1.84]
3 Global severity at 2‐4 months	6	275	Std. Mean Difference (IV, Random, 95% CI)	‐0.46 [‐0.71, ‐0.21]
3.1 Behaviour therapy	4	183	Std. Mean Difference (IV, Random, 95% CI)	‐0.62 [‐0.92, ‐0.32]
3.2 Cognitive‐behaviour therapy	2	92	Std. Mean Difference (IV, Random, 95% CI)	‐0.12 [‐0.56, 0.32]
4 Frequency of panic attacks at 2‐4 months	7	329	Std. Mean Difference (IV, Random, 95% CI)	0.04 [‐0.22, 0.29]
4.1 Behaviour therapy	5	182	Std. Mean Difference (IV, Random, 95% CI)	0.20 [‐0.09, 0.49]
4.2 Cognitive‐behaviour therapy	2	147	Std. Mean Difference (IV, Random, 95% CI)	‐0.17 [‐0.60, 0.25]
5 Phobic avoidance at 2‐4 months	11	424	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.35, 0.04]
5.1 Behaviour therapy	6	240	Std. Mean Difference (IV, Random, 95% CI)	‐0.16 [‐0.49, 0.16]
5.2 Cognitive‐behaviour therapy	5	184	Std. Mean Difference (IV, Random, 95% CI)	‐0.13 [‐0.43, 0.17]
6 General anxiety at 2‐4 months	9	426	Std. Mean Difference (IV, Random, 95% CI)	‐0.35 [‐0.55, ‐0.16]
6.1 Behaviour therapy	4	175	Std. Mean Difference (IV, Random, 95% CI)	‐0.46 [‐0.76, ‐0.16]
6.2 Cognitive‐behaviour therapy	5	251	Std. Mean Difference (IV, Random, 95% CI)	‐0.27 [‐0.53, ‐0.02]
7 Depression at 2‐4 months	8	286	Std. Mean Difference (IV, Random, 95% CI)	‐0.17 [‐0.41, 0.06]
7.1 Behaviour therapy	5	194	Std. Mean Difference (IV, Random, 95% CI)	‐0.22 [‐0.52, 0.09]
7.2 Cognitive‐behaviour therapy	3	92	Std. Mean Difference (IV, Random, 95% CI)	‐0.07 [‐0.47, 0.34]
8 Social functioning at 2‐4 months	8	319	Std. Mean Difference (IV, Random, 95% CI)	0.06 [‐0.27, 0.39]
8.1 Behaviour therapy	4	175	Std. Mean Difference (IV, Random, 95% CI)	0.10 [‐0.51, 0.71]
8.2 Cognitive‐behaviour therapy	4	144	Std. Mean Difference (IV, Random, 95% CI)	‐0.04 [‐0.39, 0.30]
9 Dropouts for any reason within 2‐4 months	10	595	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.77, 1.45]
9.1 Behaviour therapy	4	257	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.67, 1.44]
9.2 Cognitive‐behaviour therapy	6	338	Risk Ratio (M‐H, Random, 95% CI)	1.35 [0.68, 2.68]
10 Dropouts due to side effects within 2‐4 months	7	450	Risk Ratio (M‐H, Random, 95% CI)	2.81 [1.29, 6.11]
10.1 Behaviour therapy	3	173	Risk Ratio (M‐H, Random, 95% CI)	1.68 [0.67, 4.18]
10.2 Cognitive‐behaviour therapy	4	277	Risk Ratio (M‐H, Random, 95% CI)	10.34 [2.41, 44.39]
11 Response/remission on continued treatment	3	185	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.82, 1.90]
11.1 Behaviour therapy	3	185	Risk Ratio (M‐H, Random, 95% CI)	1.25 [0.82, 1.90]
11.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
12 Global/Avoidance/Panic on continued treatment	2	72	Std. Mean Difference (IV, Random, 95% CI)	‐0.96 [‐1.65, ‐0.27]
12.1 Behaviour therapy	2	72	Std. Mean Difference (IV, Random, 95% CI)	‐0.96 [‐1.65, ‐0.27]
12.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
13 Dropouts for any reason on continued treatment	1	19	Risk Ratio (M‐H, Random, 95% CI)	2.73 [0.12, 59.57]
13.1 Behaviour therapy	1	19	Risk Ratio (M‐H, Random, 95% CI)	2.73 [0.12, 59.57]
13.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
14 Response/remission 6 months after treatment discontinuation	6	297	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.80, 1.52]
14.1 Behaviour therapy	3	152	Risk Ratio (M‐H, Random, 95% CI)	1.42 [0.61, 3.32]
14.2 Cognitive‐behaviour therapy	3	145	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.71, 1.45]
15 Global/Avoidance/Panic 6 months after treatment discontinuation	3	90	Std. Mean Difference (IV, Random, 95% CI)	0.03 [‐0.43, 0.49]
15.1 Behaviour therapy	3	90	Std. Mean Difference (IV, Random, 95% CI)	0.03 [‐0.43, 0.49]
15.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
16 Response/remission 18‐24 months after treatment discontinuation	4	236	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.75, 1.43]
16.1 Behaviour therapy	4	236	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.75, 1.43]
16.2 Cognitive‐behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
17 Global/Avoidance/Panic 18‐24 months after treatment discontinuation	3	87	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.59, 0.75]
17.1 Behaviour therapy	3	87	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.59, 0.75]
17.2 Cognitive‐behviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]