Comparison 16.
SENSITIVITY2: demonstrated effectiveness: Psychotherapy+Antidepressant vs Antidepressant alone
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 4 | 348 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [0.95, 1.61] |
| 1.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 0.96 [0.69, 1.35] |
| 1.2 Cognitive‐behaviour therapy | 3 | 252 | Risk Ratio (M‐H, Random, 95% CI) | 1.36 [1.01, 1.84] |
| 1.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Remission at 2‐4 months | 4 | 348 | Risk Ratio (M‐H, Random, 95% CI) | 1.27 [0.91, 1.78] |
| 2.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 0.94 [0.52, 1.72] |
| 2.2 Cognitive‐behaviour therapy | 3 | 252 | Risk Ratio (M‐H, Random, 95% CI) | 1.40 [0.92, 2.14] |
| 2.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Global severity at 2‐4 months | 3 | 281 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.25 [‐0.49, ‐0.02] |
| 3.1 Behaviour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.14 [‐0.60, 0.31] |
| 3.2 Cognitive‐behaviour therapy | 2 | 206 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.57, ‐0.02] |
| 3.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.32 [‐0.78, 0.14] |
| 4.1 Behaviour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.32 [‐0.78, 0.14] |
| 4.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Phobic avoidance at 2‐4 months | 2 | 105 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.52 [‐1.44, 0.39] |
| 5.1 Behaviour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.11 [‐0.56, 0.35] |
| 5.2 Cognitive‐behaviour therapy | 1 | 30 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.05 [‐1.82, ‐0.28] |
| 5.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 3 | 163 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.38 [‐0.74, ‐0.03] |
| 6.1 Behaviour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.13 [‐0.58, 0.33] |
| 6.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.58 [‐1.01, ‐0.15] |
| 6.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 2 | 105 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.54 [‐1.13, 0.05] |
| 7.1 Behaviour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.31 [‐0.77, 0.15] |
| 7.2 Cognitive‐behaviour therapy | 1 | 30 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.93 [‐1.69, ‐0.17] |
| 7.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 3 | 163 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.43 [‐0.89, 0.04] |
| 8.1 Behavour therapy | 1 | 75 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.17 [‐0.62, 0.29] |
| 8.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.63 [‐1.39, 0.12] |
| 8.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Dropouts for any reason within 2‐4 months | 4 | 348 | Risk Ratio (M‐H, Random, 95% CI) | 0.76 [0.55, 1.07] |
| 9.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 0.92 [0.43, 1.99] |
| 9.2 Cognitive‐behaviour therapy | 3 | 252 | Risk Ratio (M‐H, Random, 95% CI) | 0.73 [0.50, 1.06] |
| 9.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Dropouts due to side effects within 2‐4 months | 2 | 222 | Risk Ratio (M‐H, Random, 95% CI) | 0.62 [0.09, 4.15] |
| 10.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10.2 Cognitive‐behaviour therapy | 2 | 222 | Risk Ratio (M‐H, Random, 95% CI) | 0.62 [0.09, 4.15] |
| 10.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11 Response/remission on continued treatment | 2 | 244 | Risk Ratio (M‐H, Random, 95% CI) | 1.57 [1.16, 2.14] |
| 11.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 1.75 [0.94, 3.25] |
| 11.2 Cognitive‐behaviour therapy | 1 | 148 | Risk Ratio (M‐H, Random, 95% CI) | 1.52 [1.07, 2.16] |
| 11.3 Psychdynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12 Global/Avoidance/Panic on continued treatment | 1 | 148 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.74, ‐0.09] |
| 12.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Cognitive‐behaviour therapy | 1 | 148 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.74, ‐0.09] |
| 12.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13 Dropouts for any reason on continued treatment | 1 | 148 | Risk Ratio (M‐H, Random, 95% CI) | 0.73 [0.22, 2.39] |
| 13.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.2 Cognitive‐behaviour therapy | 1 | 148 | Risk Ratio (M‐H, Random, 95% CI) | 0.73 [0.22, 2.39] |
| 13.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 16 Response/remission 6‐24 months after treatment discontinuation | 4 | 336 | Risk Ratio (M‐H, Random, 95% CI) | 1.47 [1.10, 1.96] |
| 16.1 Behaviour therapy | 1 | 96 | Risk Ratio (M‐H, Random, 95% CI) | 1.49 [0.95, 2.35] |
| 16.2 Cognitive‐behaviour therapy | 3 | 240 | Risk Ratio (M‐H, Random, 95% CI) | 1.46 [1.00, 2.11] |
| 16.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 1 | 136 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [‐0.34, 0.34] |
| 17.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.2 Cognitive‐behaviour therapy | 1 | 136 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [‐0.34, 0.34] |
| 17.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |