Comparison 17.
SENSITIVITY2: demonstrated effectiveness: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 9 | 546 | Risk Ratio (M‐H, Random, 95% CI) | 1.14 [0.96, 1.35] |
| 1.1 Behaviour therapy | 3 | 153 | Risk Ratio (M‐H, Random, 95% CI) | 1.39 [0.96, 2.00] |
| 1.2 Cognitive‐behaviour therapy | 6 | 393 | Risk Ratio (M‐H, Random, 95% CI) | 1.07 [0.89, 1.28] |
| 1.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Remission at 2‐4 months | 10 | 560 | Risk Ratio (M‐H, Random, 95% CI) | 1.11 [0.95, 1.29] |
| 2.1 Behaviour therapy | 4 | 167 | Risk Ratio (M‐H, Random, 95% CI) | 1.22 [0.75, 2.00] |
| 2.2 Cognitive‐behaviour therapy | 6 | 393 | Risk Ratio (M‐H, Random, 95% CI) | 1.08 [0.91, 1.29] |
| 2.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Global severity at 2‐4 months | 7 | 421 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.36 [‐0.57, ‐0.15] |
| 3.1 Behaviour therapy | 3 | 124 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.71 [‐1.08, ‐0.33] |
| 3.2 Cognitive‐behaviour therapy | 4 | 297 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.21 [‐0.46, 0.04] |
| 3.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 5 | 173 | Std. Mean Difference (IV, Random, 95% CI) | 0.05 [‐0.36, 0.46] |
| 4.1 Behaviour therapy | 4 | 135 | Std. Mean Difference (IV, Random, 95% CI) | 0.10 [‐0.43, 0.63] |
| 4.2 Cognitive‐behaviour therapy | 1 | 38 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.15 [‐0.79, 0.49] |
| 5 Phobic avoidance at 2‐4 months | 8 | 296 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.38 [‐0.65, ‐0.12] |
| 5.1 Behaviour therapy | 4 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.55 [‐1.10, 0.00] |
| 5.2 Cognitive‐behaviour therapy | 4 | 158 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.23 [‐0.56, 0.09] |
| 5.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 8 | 296 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.37 [‐0.61, ‐0.12] |
| 6.1 Behaviour therapy | 4 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.66 [‐1.01, ‐0.30] |
| 6.2 Cognitive‐behaviour therapy | 4 | 158 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.12 [‐0.45, 0.20] |
| 6.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 5 | 166 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.53 [‐0.86, ‐0.20] |
| 7.1 Behaviour therapy | 4 | 138 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.62 [‐0.99, ‐0.25] |
| 7.2 Cognitive‐behaviour therapy | 1 | 28 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.16 [‐0.90, 0.58] |
| 7.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 4 | 188 | Std. Mean Difference (IV, Random, 95% CI) | 0.13 [‐0.39, 0.66] |
| 8.1 Behaviour therapy | 1 | 68 | Std. Mean Difference (IV, Random, 95% CI) | 0.78 [0.28, 1.27] |
| 8.2 Cognitive‐behaviour therapy | 3 | 120 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.14 [‐0.52, 0.24] |
| 9 Dropouts for any reason within 2‐4 months | 10 | 560 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [0.84, 1.61] |
| 9.1 Behaviour therapy | 4 | 167 | Risk Ratio (M‐H, Random, 95% CI) | 1.21 [0.62, 2.35] |
| 9.2 Cognitive‐behaviour therapy | 6 | 393 | Risk Ratio (M‐H, Random, 95% CI) | 1.15 [0.79, 1.67] |
| 9.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Dropouts due to side effects within 2‐4 months | 7 | 434 | Risk Ratio (M‐H, Random, 95% CI) | 4.18 [1.53, 11.45] |
| 10.1 Behaviour therapy | 2 | 69 | Risk Ratio (M‐H, Random, 95% CI) | 5.41 [0.59, 49.42] |
| 10.2 Cognitive‐behaviour therapy | 5 | 365 | Risk Ratio (M‐H, Random, 95% CI) | 3.91 [1.26, 12.12] |
| 11 Response/remission on continued treatment | 3 | 289 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [0.91, 1.49] |
| 11.1 Behaviour therapy | 1 | 84 | Risk Ratio (M‐H, Random, 95% CI) | 0.95 [0.57, 1.60] |
| 11.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [0.93, 1.63] |
| 12 Global/Avoidance/Panic on continued treatment | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.71, ‐0.12] |
| 12.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Cognitive‐behaviour therapy | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.71, ‐0.12] |
| 13 Dropouts for any reason on continued treatment | 3 | 243 | Risk Ratio (M‐H, Random, 95% CI) | 0.78 [0.28, 2.16] |
| 13.1 Behaviour therapy | 1 | 38 | Risk Ratio (M‐H, Random, 95% CI) | 3.00 [0.13, 69.31] |
| 13.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.66 [0.22, 1.95] |
| 14 Response/remission 6‐24 months after treatment discontinuation | 8 | 485 | Risk Ratio (M‐H, Random, 95% CI) | 0.95 [0.77, 1.18] |
| 14.1 Behaviour therapy | 3 | 146 | Risk Ratio (M‐H, Random, 95% CI) | 1.01 [0.73, 1.41] |
| 14.2 Cognitive‐behaviour therapy | 5 | 339 | Risk Ratio (M‐H, Random, 95% CI) | 0.91 [0.69, 1.21] |
| 15 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 4 | 248 | Std. Mean Difference (IV, Random, 95% CI) | 0.16 [‐0.11, 0.43] |
| 15.1 Behaviour therapy | 2 | 54 | Std. Mean Difference (IV, Random, 95% CI) | 0.01 [‐0.56, 0.58] |
| 15.2 Cognitive‐behaviour therapy | 2 | 194 | Std. Mean Difference (IV, Random, 95% CI) | 0.21 [‐0.10, 0.52] |