Comparison 18.
SENSITIVITY3: operationalised criteria: Psychotherapy+Antidepressant vs Antidepressant alone
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 8 | 501 | Risk Ratio (M‐H, Random, 95% CI) | 1.38 [1.03, 1.85] |
| 1.1 Behaviour therapy | 1 | 25 | Risk Ratio (M‐H, Random, 95% CI) | 4.62 [0.63, 34.05] |
| 1.2 Cognitive‐behaviour therapy | 5 | 336 | Risk Ratio (M‐H, Random, 95% CI) | 1.46 [1.05, 2.02] |
| 1.3 Psychodynamic psychotherapy and others | 2 | 140 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [0.61, 2.20] |
| 2 Remission at 2‐4 months | 5 | 392 | Risk Ratio (M‐H, Random, 95% CI) | 1.17 [0.82, 1.67] |
| 2.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2.2 Cognitive‐behaviour therapy | 3 | 252 | Risk Ratio (M‐H, Random, 95% CI) | 1.40 [0.92, 2.14] |
| 2.3 Psychodynamic psychotherapy and others | 2 | 140 | Risk Ratio (M‐H, Random, 95% CI) | 0.86 [0.28, 2.61] |
| 3 Global severity at 2‐4 months | 3 | 246 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.36 [‐0.61, ‐0.10] |
| 3.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3.2 Cognitive‐behaviour therapy | 2 | 206 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.57, ‐0.02] |
| 3.3 Psychodynamic psychotherapy and others | 1 | 40 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.69 [‐1.33, ‐0.05] |
| 4 Frequency of panic attacks at 2‐4 months | 5 | 237 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.28 [‐0.84, 0.28] |
| 4.1 Behaviour therapy | 1 | 20 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.14 [‐1.01, 0.74] |
| 4.2 Cognitive‐behaviour therapy | 3 | 125 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.46 [‐1.42, 0.50] |
| 4.3 Psychodynamic psychotherapy and others | 2 | 92 | Std. Mean Difference (IV, Random, 95% CI) | 0.03 [‐0.53, 0.59] |
| 5 Phobic avoidance at 2‐4 months | 5 | 233 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.15 [‐0.74, 0.44] |
| 5.1 Behaviour therapy | 1 | 20 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.99 [‐1.93, ‐0.05] |
| 5.2 Cognitive‐behaviour therapy | 3 | 121 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.03 [‐0.93, 0.87] |
| 5.3 Psychodynamic psychotherapy and others | 2 | 92 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.01 [‐1.15, 1.13] |
| 6 General anxiety at 2‐4 months | 5 | 266 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.49 [‐1.10, 0.12] |
| 6.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6.2 Cognitive‐behaviour therapy | 4 | 174 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.51 [‐1.20, 0.18] |
| 6.3 Psychodynamic psychotherapy and others | 2 | 92 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.45 [‐2.12, 1.22] |
| 7 Depression at 2‐4 months | 5 | 163 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.61 [‐0.93, ‐0.29] |
| 7.1 Behaviour therapy | 1 | 20 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.12 [‐0.99, 0.76] |
| 7.2 Cognitive‐behaviour therapy | 3 | 103 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.65 [‐1.10, ‐0.20] |
| 7.3 Psychodynamic psychotherapy and others | 1 | 40 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.79 [‐1.44, ‐0.14] |
| 8 Social functioning at 2‐4 months | 3 | 128 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.66 [‐1.12, ‐0.20] |
| 8.1 Behavour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.63 [‐1.39, 0.12] |
| 8.3 Psychodynamic psychotherapy and others | 1 | 40 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.81 [‐1.46, ‐0.16] |
| 9 Dropouts for any reason within 2‐4 months | 7 | 401 | Risk Ratio (M‐H, Random, 95% CI) | 0.80 [0.58, 1.11] |
| 9.1 Behaviour therapy | 1 | 25 | Risk Ratio (M‐H, Random, 95% CI) | 1.38 [0.28, 6.91] |
| 9.2 Cognitive‐behaviour therapy | 5 | 336 | Risk Ratio (M‐H, Random, 95% CI) | 0.77 [0.55, 1.08] |
| 9.3 Psychodynamic psychotherapy and others | 1 | 40 | Risk Ratio (M‐H, Random, 95% CI) | 3.00 [0.13, 69.52] |
| 10 Dropouts due to side effects within 2‐4 months | 5 | 327 | Risk Ratio (M‐H, Random, 95% CI) | 0.99 [0.44, 2.24] |
| 10.1 Behaviour therapy | 1 | 25 | Risk Ratio (M‐H, Random, 95% CI) | 1.38 [0.28, 6.91] |
| 10.2 Cognitive‐behaviour therapy | 3 | 262 | Risk Ratio (M‐H, Random, 95% CI) | 0.81 [0.25, 2.68] |
| 10.3 Psychodynamic psychotherapy and others | 1 | 40 | Risk Ratio (M‐H, Random, 95% CI) | 3.00 [0.13, 69.52] |
| 11 Response/remission on continued treatment | 4 | 286 | Risk Ratio (M‐H, Random, 95% CI) | 1.26 [0.59, 2.67] |
| 11.1 Behaviour therapy | 1 | 25 | Risk Ratio (M‐H, Random, 95% CI) | 3.23 [0.83, 12.61] |
| 11.2 Cognitive‐behaviour therapy | 1 | 148 | Risk Ratio (M‐H, Random, 95% CI) | 1.52 [1.07, 2.16] |
| 11.3 Psychdynamic psychotherapy and others | 2 | 113 | Risk Ratio (M‐H, Random, 95% CI) | 0.67 [0.44, 1.02] |
| 12 Global/Avoidance/Panic on continued treatment | 4 | 258 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.45 [‐1.04, 0.15] |
| 12.1 Behaviour therapy | 1 | 20 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.23 [‐2.20, ‐0.26] |
| 12.2 Cognitive‐behaviour therapy | 1 | 148 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.74, ‐0.09] |
| 12.3 Psychodynamic psychotherapy and others | 2 | 90 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.20 [‐1.45, 1.04] |
| 13 Dropouts for any reason on continued treatment | 3 | 208 | Risk Ratio (M‐H, Random, 95% CI) | 0.71 [0.27, 1.90] |
| 13.1 Behaviour therapy | 1 | 20 | Risk Ratio (M‐H, Random, 95% CI) | 1.0 [0.07, 13.87] |
| 13.2 Cognitive‐behaviour therapy | 1 | 148 | Risk Ratio (M‐H, Random, 95% CI) | 0.73 [0.22, 2.39] |
| 13.3 Psychodynamic psychotherapy and others | 1 | 40 | Risk Ratio (M‐H, Random, 95% CI) | 0.5 [0.05, 5.08] |
| 16 Response/remission 6‐24 months after treatment discontinuation | 4 | 280 | Risk Ratio (M‐H, Random, 95% CI) | 1.68 [1.19, 2.38] |
| 16.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 16.2 Cognitive‐behaviour therapy | 3 | 240 | Risk Ratio (M‐H, Random, 95% CI) | 1.46 [1.00, 2.11] |
| 16.3 Psychodynamic psychotherapy and others | 1 | 40 | Risk Ratio (M‐H, Random, 95% CI) | 3.2 [1.45, 7.05] |
| 17 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 2 | 176 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.58 [‐1.78, 0.63] |
| 17.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.2 Cognitive‐behaviour therapy | 1 | 136 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [‐0.34, 0.34] |
| 17.3 Psychodynamic psychotherapy and others | 1 | 40 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.23 [‐1.91, ‐0.55] |