Comparison 19.
SENSITIVITY3: operationalised criteria: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 16 | 883 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [1.01, 1.35] |
| 1.1 Behaviour therapy | 5 | 174 | Risk Ratio (M‐H, Random, 95% CI) | 1.34 [0.97, 1.86] |
| 1.2 Cognitive‐behaviour therapy | 11 | 709 | Risk Ratio (M‐H, Random, 95% CI) | 1.13 [0.96, 1.33] |
| 1.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Remission at 2‐4 months | 14 | 788 | Risk Ratio (M‐H, Random, 95% CI) | 1.22 [1.05, 1.42] |
| 2.1 Behaviour therapy | 5 | 163 | Risk Ratio (M‐H, Random, 95% CI) | 1.22 [0.88, 1.68] |
| 2.2 Cognitive‐behaviour therapy | 9 | 625 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [1.02, 1.47] |
| 2.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Global severity at 2‐4 months | 9 | 481 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.37 [‐0.56, ‐0.18] |
| 3.1 Behaviour therapy | 4 | 118 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.54 [‐0.92, ‐0.16] |
| 3.2 Cognitive‐behaviour therapy | 5 | 363 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.31 [‐0.54, ‐0.08] |
| 3.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 10 | 367 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.12 [‐0.33, 0.08] |
| 4.1 Behaviour therapy | 6 | 148 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.09 [‐0.42, 0.24] |
| 4.2 Cognitive‐behaviour therapy | 4 | 219 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.15 [‐0.41, 0.12] |
| 5 Phobic avoidance at 2‐4 months | 13 | 439 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.28 [‐0.47, ‐0.08] |
| 5.1 Behaviour therapy | 6 | 151 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.43 [‐0.85, ‐0.00] |
| 5.2 Cognitive‐behaviour therapy | 7 | 288 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.20 [‐0.44, 0.04] |
| 5.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 13 | 521 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.47, ‐0.12] |
| 6.1 Behaviour therapy | 5 | 132 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.49 [‐0.87, ‐0.11] |
| 6.2 Cognitive‐behaviour therapy | 8 | 389 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.23 [‐0.44, ‐0.03] |
| 6.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 11 | 343 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.35 [‐0.58, ‐0.12] |
| 7.1 Behaviour therapy | 6 | 151 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.36 [‐0.77, 0.05] |
| 7.2 Cognitive‐behaviour therapy | 5 | 192 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.34 [‐0.64, ‐0.05] |
| 7.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 6 | 206 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.17 [‐0.45, 0.12] |
| 8.1 Behaviour therapy | 2 | 62 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.44 [‐0.94, 0.07] |
| 8.2 Cognitive‐behaviour therapy | 4 | 144 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.04 [‐0.39, 0.30] |
| 9 Dropouts for any reason within 2‐4 months | 14 | 773 | Risk Ratio (M‐H, Random, 95% CI) | 1.15 [0.84, 1.56] |
| 9.1 Behaviour therapy | 4 | 108 | Risk Ratio (M‐H, Random, 95% CI) | 1.09 [0.48, 2.45] |
| 9.2 Cognitive‐behaviour therapy | 10 | 665 | Risk Ratio (M‐H, Random, 95% CI) | 1.16 [0.83, 1.62] |
| 9.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Dropouts due to side effects within 2‐4 months | 11 | 698 | Risk Ratio (M‐H, Random, 95% CI) | 4.65 [2.09, 10.32] |
| 10.1 Behaviour therapy | 3 | 94 | Risk Ratio (M‐H, Random, 95% CI) | 3.82 [0.83, 17.66] |
| 10.2 Cognitive‐behaviour therapy | 8 | 604 | Risk Ratio (M‐H, Random, 95% CI) | 5.00 [1.96, 12.72] |
| 11 Response/remission on continued treatment | 3 | 230 | Risk Ratio (M‐H, Random, 95% CI) | 1.29 [0.95, 1.76] |
| 11.1 Behaviour therapy | 1 | 25 | Risk Ratio (M‐H, Random, 95% CI) | 3.23 [0.83, 12.61] |
| 11.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 1.23 [0.93, 1.63] |
| 12 Global/Avoidance/Panic on continued treatment | 3 | 224 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.56 [‐0.99, ‐0.13] |
| 12.1 Behaviour therapy | 1 | 19 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.47 [‐2.51, ‐0.43] |
| 12.2 Cognitive‐behaviour therapy | 2 | 205 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.41 [‐0.71, ‐0.12] |
| 13 Dropouts for any reason on continued treatment | 4 | 262 | Risk Ratio (M‐H, Random, 95% CI) | 0.88 [0.33, 2.32] |
| 13.1 Behaviour therapy | 2 | 57 | Risk Ratio (M‐H, Random, 95% CI) | 2.86 [0.32, 25.80] |
| 13.2 Cognitive‐behaviour therapy | 2 | 205 | Risk Ratio (M‐H, Random, 95% CI) | 0.66 [0.22, 1.95] |
| 14 Response/remission 6‐24 months after treatment discontinuation | 10 | 502 | Risk Ratio (M‐H, Random, 95% CI) | 0.93 [0.74, 1.17] |
| 14.1 Behaviour therapy | 5 | 163 | Risk Ratio (M‐H, Random, 95% CI) | 0.98 [0.67, 1.45] |
| 14.2 Cognitive‐behaviour therapy | 5 | 339 | Risk Ratio (M‐H, Random, 95% CI) | 0.91 [0.69, 1.21] |
| 15 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 6 | 295 | Std. Mean Difference (IV, Random, 95% CI) | 0.13 [‐0.13, 0.40] |
| 15.1 Behaviour therapy | 4 | 101 | Std. Mean Difference (IV, Random, 95% CI) | 0.02 [‐0.49, 0.53] |
| 15.2 Cognitive‐behaviour therapy | 2 | 194 | Std. Mean Difference (IV, Random, 95% CI) | 0.21 [‐0.10, 0.52] |