Comparison 20.
SENSITIVITY5: without benzo: Psychotherapy+Antidepressant vs Antidepressant alone
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 3 | 122 | Risk Ratio (M‐H, Random, 95% CI) | 1.37 [0.91, 2.05] |
| 1.1 Behaviour therapy | 1 | 18 | Risk Ratio (M‐H, Random, 95% CI) | 1.17 [0.65, 2.08] |
| 1.2 Cognitive‐behaviour therapy | 2 | 104 | Risk Ratio (M‐H, Random, 95% CI) | 1.59 [0.75, 3.34] |
| 1.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Remission at 2‐4 months | 3 | 122 | Risk Ratio (M‐H, Random, 95% CI) | 1.40 [0.72, 2.73] |
| 2.1 Behaviour therapy | 1 | 18 | Risk Ratio (M‐H, Random, 95% CI) | 1.0 [0.52, 1.92] |
| 2.2 Cognitive‐behaviour therapy | 2 | 104 | Risk Ratio (M‐H, Random, 95% CI) | 2.13 [0.45, 10.10] |
| 2.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Global severity at 2‐4 months | 2 | 73 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.62 [‐1.14, ‐0.10] |
| 3.1 Behaviour therapy | 1 | 15 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.14 [‐2.26, ‐0.02] |
| 3.2 Cognitive‐behaviour therapy | 1 | 58 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.48 [‐1.01, 0.04] |
| 3.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 1 | 15 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.22 [‐1.24, 0.80] |
| 4.1 Behaviour therapy | 1 | 15 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.22 [‐1.24, 0.80] |
| 4.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Phobic avoidance at 2‐4 months | 3 | 103 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.65 [‐1.37, 0.07] |
| 5.1 Behaviour therapy | 1 | 15 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.07 [‐2.18, 0.04] |
| 5.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.53 [‐1.45, 0.39] |
| 5.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 3 | 103 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.57 [‐0.96, ‐0.17] |
| 6.1 Behaviour therapy | 1 | 15 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.49 [‐1.53, 0.54] |
| 6.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.58 [‐1.01, ‐0.15] |
| 6.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 2 | 45 | Std. Mean Difference (IV, Random, 95% CI) | 1.00 [‐1.63, ‐0.37] |
| 7.1 Behaviour therapy | 1 | 15 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.14 [‐2.26, ‐0.02] |
| 7.2 Cognitive‐behaviour therapy | 1 | 30 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.93 [‐1.69, ‐0.17] |
| 7.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 3 | 103 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.70 [‐1.26, ‐0.13] |
| 8.1 Behavour therapy | 1 | 15 | Std. Mean Difference (IV, Random, 95% CI) | ‐1.05 [‐2.15, 0.06] |
| 8.2 Cognitive‐behaviour therapy | 2 | 88 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.63 [‐1.39, 0.12] |
| 8.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Dropouts for any reason within 2‐4 months | 3 | 122 | Risk Ratio (M‐H, Random, 95% CI) | 0.73 [0.41, 1.28] |
| 9.1 Behaviour therapy | 1 | 18 | Risk Ratio (M‐H, Random, 95% CI) | 0.5 [0.05, 4.58] |
| 9.2 Cognitive‐behaviour therapy | 2 | 104 | Risk Ratio (M‐H, Random, 95% CI) | 0.75 [0.42, 1.34] |
| 9.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Dropouts due to side effects within 2‐4 months | 2 | 92 | Risk Ratio (M‐H, Random, 95% CI) | 1.15 [0.36, 3.67] |
| 10.1 Behaviour therapy | 1 | 18 | Risk Ratio (M‐H, Random, 95% CI) | 0.5 [0.05, 4.58] |
| 10.2 Cognitive‐behaviour therapy | 1 | 74 | Risk Ratio (M‐H, Random, 95% CI) | 1.58 [0.41, 6.13] |
| 10.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11 Response/remission on continued treatment | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.3 Psychdynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12 Global/Avoidance/Panic on continued treatment | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13 Dropouts for any reason on continued treatment | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 16 Response/remission 6‐24 months after treatment discontinuation | 2 | 104 | Risk Ratio (M‐H, Random, 95% CI) | 1.49 [0.94, 2.38] |
| 16.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 16.2 Cognitive‐behaviour therapy | 2 | 104 | Risk Ratio (M‐H, Random, 95% CI) | 1.49 [0.94, 2.38] |
| 16.3 Psychodynamic psychotherapy and others | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 17.3 Psychodynamic psychotherapy and others | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |