Comparison 21.
SENSITIVITY5: without benzo: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Response at 2‐4 months | 8 | 481 | Risk Ratio (M‐H, Random, 95% CI) | 1.26 [1.06, 1.51] |
| 1.1 Behaviour therapy | 3 | 159 | Risk Ratio (M‐H, Random, 95% CI) | 1.48 [1.00, 2.18] |
| 1.2 Cognitive‐behaviour therapy | 5 | 322 | Risk Ratio (M‐H, Random, 95% CI) | 1.22 [0.96, 1.55] |
| 1.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 2 Remission at 2‐4 months | 9 | 536 | Risk Ratio (M‐H, Random, 95% CI) | 1.32 [1.08, 1.61] |
| 2.1 Behaviour therapy | 3 | 159 | Risk Ratio (M‐H, Random, 95% CI) | 1.27 [0.84, 1.93] |
| 2.2 Cognitive‐behaviour therapy | 6 | 377 | Risk Ratio (M‐H, Random, 95% CI) | 1.33 [1.02, 1.73] |
| 2.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Global severity at 2‐4 months | 3 | 158 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.35 [‐0.81, 0.10] |
| 3.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3.2 Cognitive‐behaviour therapy | 3 | 158 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.35 [‐0.81, 0.10] |
| 3.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4 Frequency of panic attacks at 2‐4 months | 1 | 107 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.33 [‐0.72, 0.05] |
| 4.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 4.2 Cognitive‐behaviour therapy | 1 | 107 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.33 [‐0.72, 0.05] |
| 5 Phobic avoidance at 2‐4 months | 8 | 312 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.32 [‐0.56, ‐0.08] |
| 5.1 Behaviour therapy | 3 | 102 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.65 [‐1.29, ‐0.01] |
| 5.2 Cognitive‐behaviour therapy | 5 | 210 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.20 [‐0.48, 0.08] |
| 5.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 6 General anxiety at 2‐4 months | 9 | 419 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.43 [‐0.67, ‐0.20] |
| 6.1 Behaviour therapy | 3 | 102 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.89 [‐1.49, ‐0.29] |
| 6.2 Cognitive‐behaviour therapy | 6 | 317 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.30 [‐0.53, ‐0.08] |
| 6.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Depression at 2‐4 months | 6 | 220 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.44 [‐0.78, ‐0.10] |
| 7.1 Behaviour therapy | 3 | 102 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.59 [‐1.33, 0.14] |
| 7.2 Cognitive‐behaviour therapy | 3 | 118 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.38 [‐0.76, ‐0.01] |
| 7.3 Psychodynamic and other therapies | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Social functioning at 2‐4 months | 6 | 201 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.31 [‐0.74, 0.11] |
| 8.1 Behaviour therapy | 2 | 57 | Std. Mean Difference (IV, Random, 95% CI) | 1.00 [‐1.57, ‐0.43] |
| 8.2 Cognitive‐behaviour therapy | 4 | 144 | Std. Mean Difference (IV, Random, 95% CI) | ‐0.04 [‐0.39, 0.30] |
| 9 Dropouts for any reason within 2‐4 months | 9 | 536 | Risk Ratio (M‐H, Random, 95% CI) | 1.18 [0.83, 1.68] |
| 9.1 Behaviour therapy | 3 | 159 | Risk Ratio (M‐H, Random, 95% CI) | 1.10 [0.67, 1.82] |
| 9.2 Cognitive‐behaviour therapy | 6 | 377 | Risk Ratio (M‐H, Random, 95% CI) | 1.28 [0.75, 2.19] |
| 9.3 Psychodynamic and other therapies | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Dropouts due to side effects within 2‐4 months | 5 | 388 | Risk Ratio (M‐H, Random, 95% CI) | 4.09 [1.03, 16.22] |
| 10.1 Behaviour therapy | 1 | 72 | Risk Ratio (M‐H, Random, 95% CI) | 0.67 [0.12, 3.75] |
| 10.2 Cognitive‐behaviour therapy | 4 | 316 | Risk Ratio (M‐H, Random, 95% CI) | 9.84 [2.30, 42.08] |
| 11 Response/remission on continued treatment | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 11.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12 Global/Avoidance/Panic on continued treatment | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.1 Behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13 Dropouts for any reason on continued treatment | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.1 Behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 13.2 Cognitive‐behaviour therapy | 0 | 0 | Risk Ratio (M‐H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 14 Response/remission 6‐24 months after treatment discontinuation | 4 | 217 | Risk Ratio (M‐H, Random, 95% CI) | 0.98 [0.71, 1.35] |
| 14.1 Behaviour therapy | 1 | 72 | Risk Ratio (M‐H, Random, 95% CI) | 0.82 [0.39, 1.73] |
| 14.2 Cognitive‐behaviour therapy | 3 | 145 | Risk Ratio (M‐H, Random, 95% CI) | 1.02 [0.71, 1.45] |
| 15 Global/Avoidance/Panic 6‐24 months after treatment discontinuation | 1 | 40 | Std. Mean Difference (IV, Random, 95% CI) | 0.14 [‐0.48, 0.77] |
| 15.1 Behaviour therapy | 1 | 40 | Std. Mean Difference (IV, Random, 95% CI) | 0.14 [‐0.48, 0.77] |
| 15.2 Cognitive‐behaviour therapy | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |