Comparison 23.

SENSITIVITY5: allowed benzo: Psychotherapy+Antidepressant vs Psychotherapy alone or +Placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Response at 2‐4 months	6	357	Risk Ratio (M‐H, Random, 95% CI)	1.32 [1.04, 1.68]
1.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	1.67 [1.00, 2.78]
1.2 Cognitive‐behaviour therapy	4	288	Risk Ratio (M‐H, Random, 95% CI)	1.20 [0.94, 1.53]
2 Remission at 2‐4 months	5	317	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.91, 1.34]
2.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	1.15 [0.79, 1.68]
2.2 Cognitive‐behaviour therapy	3	248	Risk Ratio (M‐H, Random, 95% CI)	1.09 [0.87, 1.36]
3 Global severity at 2‐4 months	4	261	Std. Mean Difference (IV, Random, 95% CI)	‐0.32 [‐0.58, ‐0.06]
3.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.58 [‐1.14, ‐0.01]
3.2 Cognitive‐behaviour therapy	2	205	Std. Mean Difference (IV, Random, 95% CI)	‐0.25 [‐0.55, 0.04]
4 Frequency of panic attacks at 2‐4 months	4	131	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.50, 0.21]
4.1 Behaviour therapy	2	53	Std. Mean Difference (IV, Random, 95% CI)	‐0.37 [‐0.95, 0.20]
4.2 Cognitive‐behaviour therapy	2	78	Std. Mean Difference (IV, Random, 95% CI)	‐0.01 [‐0.45, 0.43]
5 Phobic avoidance at 2‐4 months	4	134	Std. Mean Difference (IV, Random, 95% CI)	‐0.52 [‐0.99, ‐0.06]
5.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.99 [‐1.57, ‐0.40]
5.2 Cognitive‐behaviour therapy	2	78	Std. Mean Difference (IV, Random, 95% CI)	‐0.19 [‐0.63, 0.26]
6 General anxiety at 2‐4 months	3	94	Std. Mean Difference (IV, Random, 95% CI)	‐0.57 [‐1.09, ‐0.05]
6.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.88 [‐1.46, ‐0.30]
6.2 Cognitive‐behaviour therapy	1	38	Std. Mean Difference (IV, Random, 95% CI)	‐0.13 [‐0.77, 0.51]
7 Depression at 2‐4 months	3	96	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐1.03, 0.17]
7.1 Behaviour therapy	2	56	Std. Mean Difference (IV, Random, 95% CI)	‐0.76 [‐1.34, ‐0.19]
7.2 Cognitive‐behaviour therapy	1	40	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.54, 0.70]
8 Social functioning at 2‐4 months	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
8.1 Behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
8.2 Cognitive‐behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
9 Dropouts for any reason within 2‐4 months	6	357	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.73, 1.65]
9.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.44, 3.22]
9.2 Cognitive‐behaviour therapy	4	288	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.69, 1.69]
10 Dropouts due to side effects within 2‐4 months	6	357	Risk Ratio (M‐H, Random, 95% CI)	3.53 [1.21, 10.27]
10.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	5.41 [0.59, 49.42]
10.2 Cognitive‐behaviour therapy	4	288	Risk Ratio (M‐H, Random, 95% CI)	3.10 [0.92, 10.50]
11 Response/remission on continued treatment	2	205	Risk Ratio (M‐H, Random, 95% CI)	1.23 [0.93, 1.63]
11.1 Behaviour therapy	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
11.2 Cognitive‐behaviour therapy	2	205	Risk Ratio (M‐H, Random, 95% CI)	1.23 [0.93, 1.63]
12 Global/Avoidance/Panic on continued treatment	2	205	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.71, ‐0.12]
12.1 Behaviour therapy	0	0	Std. Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
12.2 Cognitive‐behaviour therapy	2	205	Std. Mean Difference (IV, Random, 95% CI)	‐0.41 [‐0.71, ‐0.12]
13 Dropouts for any reason on continued treatment	3	243	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.28, 2.16]
13.1 Behaviour therapy	1	38	Risk Ratio (M‐H, Random, 95% CI)	3.00 [0.13, 69.31]
13.2 Cognitive‐behaviour therapy	2	205	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.22, 1.95]
14 Response/remission 6‐24 months after treatment discontinuation	4	263	Risk Ratio (M‐H, Random, 95% CI)	0.87 [0.61, 1.22]
14.1 Behaviour therapy	2	69	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.62, 1.69]
14.2 Cognitive‐behaviour therapy	2	194	Risk Ratio (M‐H, Random, 95% CI)	0.74 [0.46, 1.19]
15 Global/Avoidance/Panic 6‐24 months after treatment discontinuation	4	248	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.11, 0.43]
15.1 Behaviour therapy	2	54	Std. Mean Difference (IV, Random, 95% CI)	0.01 [‐0.56, 0.58]
15.2 Cognitive‐behaviour therapy	2	194	Std. Mean Difference (IV, Random, 95% CI)	0.21 [‐0.10, 0.52]