Methods | ALLOCATION CONCEALMENT: unclear BLINDING: at least one measure was assessed by an independent assessor blind to treatment allocation | |
Participants | DIAGNOSIS: DSM‐III agoraphobia with panic attacks AGE: mean=41.5 years SEX: 92% women HISTORY: mean duration of illness=12.2 years PSYCHIATRIC COMORBIDITY: None met criteria for major affective disorder. MEDICAL COMORBIDITY: | |
Interventions | ACUTE PHASE: 8 weeks 1. imipramine (ca 180 mg/d) + behavior therapy (three 3‐hour group sessions + three 1.5‐hour individual sessions) 2. imipramine (with anti‐exposure) 3. placebo + behavior therapy ACUTE PHASE CO‐INTERVENTION: not specified MAINTENANCE: 18 weeks MODE OF DISCONTINUATION: ‐ FOLLOW‐UP: ‐ |
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Outcomes | RESPONSE: >=50% reduction in FQ‐Ag [imputed from mean&SD] REMISSION: GLOBAL: ‐ PANIC ATTACK: frequency of panic attacks AGORAPHOBIA: FQ‐Ag; BAT GENERAL ANXIETY: ‐ DEPRESSION: Beck Depression Inventory FUNCTIONING: ‐ | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |