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. 2007 Jan 24;2007(1):CD004364. doi: 10.1002/14651858.CD004364.pub2
Methods ALLOCATION CONCEALMENT: unclear BLINDING: at least one measure was assessed by an independent assessor blind to treatment allocation
Participants DIAGNOSIS: DSM‐III agoraphobia with panic attacks AGE: mean=41.5 years SEX: 92% women HISTORY: mean duration of illness=12.2 years PSYCHIATRIC COMORBIDITY: None met criteria for major affective disorder. MEDICAL COMORBIDITY:
Interventions ACUTE PHASE: 8 weeks 1. imipramine (ca 180 mg/d) + behavior therapy (three 3‐hour group sessions + three 1.5‐hour individual sessions) 2. imipramine (with anti‐exposure) 3. placebo + behavior therapy
ACUTE PHASE CO‐INTERVENTION: not specified
MAINTENANCE: 18 weeks
MODE OF DISCONTINUATION: ‐
FOLLOW‐UP: ‐
Outcomes RESPONSE: >=50% reduction in FQ‐Ag [imputed from mean&SD] REMISSION: GLOBAL: ‐ PANIC ATTACK: frequency of panic attacks AGORAPHOBIA: FQ‐Ag; BAT GENERAL ANXIETY: ‐ DEPRESSION: Beck Depression Inventory FUNCTIONING: ‐
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear