Comparison 2. Pre‐hospital versus in‐hospital thrombolysis morbidity.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Time to thrombolytic treatment	2	438	Mean Difference (IV, Random, 95% CI)	‐37.95 [‐61.12, ‐14.77]
2 Acute myocardial infarction functional outcomes	2	416	Mean Difference (IV, Fixed, 95% CI)	‐1.18 [‐3.50, 1.13]
2.1 Ejection Fraction [Percentage]	2	416	Mean Difference (IV, Fixed, 95% CI)	‐1.18 [‐3.50, 1.13]
3 Adverse effects	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Ventricullar Fribrillation	2	178	Risk Ratio (M‐H, Fixed, 95% CI)	2.73 [0.68, 10.86]
3.2 Hypotension	2	178	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.47, 3.49]
3.3 Bleeding complications	2	438	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.41, 1.92]
3.4 Allergic Reaction	1	100	Risk Ratio (M‐H, Fixed, 95% CI)	3.79 [0.19, 77.03]
3.5 Intubation	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.06, 14.65]
3.6 Cardiac Massage	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.55]
3.7 Ventricular tachycardia	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	1.27 [0.48, 3.31]
3.8 Wrong Diagnosis	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	2.85 [0.12, 67.97]
3.9 Pulmonary Congestion	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.40, 2.28]
3.10 Post‐infact Angina	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.14, 6.41]
3.11 Bradycardia	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.15, 2.22]
3.12 Reinfaction	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.22, 2.62]
3.13 Percutaneous transluminal coronary angioplasty	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	3.8 [0.44, 32.49]
3.14 Coronary Artery Bypass Graft	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	2.85 [0.12, 67.97]
3.15 Stroke	1	360	Risk Ratio (M‐H, Fixed, 95% CI)	2.11 [0.39, 11.40]