Adair 1999.
Methods | No information of randomisation, allocation concealment and blinding. | |
Participants |
Intervention group: 123 pregnant women (mean age 24.8, SD 3.7), (mean gestational age 39.8, SD 1.9) with intrapartum diagnosis of MSAF. Control group: 119 pregnant women (mean age 23.4, SD 3.4), (mean gestational age 39.8, SD 1.1) with intrapartum diagnosis of MSAF. Inclusion criteria: absence of obvious infection, temperature < 100 F, MSAF passage and willingness to participate. Exclusion criteria: fetal heart rate > 180, penicillin or cephalosporin allergy. |
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Interventions |
Intervention: ampicillin‐sulbactam 3.0 g intravenous. Control: normal saline. |
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Outcomes | Intra‐ amniotic infection. | |
Notes | Data from conference abstract. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described. |
Allocation concealment (selection bias) | Unclear risk | Not described. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not described. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No loss of follow up. |
Selective reporting (reporting bias) | Unclear risk | Not described. |
Other bias | Unclear risk | Not described. |
GA: gestational age IV: intravenous MSAF: meconium‐stained amniotic fluid NICU: neonatal intensive care unit RCT: randomised controlled trial SD: standard deviation